PMID: 6404149Apr 1, 1983Paper

Comparison of slow-release pindolol, standard pindolol, and propranolol in angina pectoris

The American Journal of Cardiology
J O Parker

Abstract

Twenty-two patients with chronic, stable, exercise-induced angina pectoris were assessed during periods of therapy with propranolol, standard-formulation pindolol, and a slow-release preparation of pindolol. Patients maintained diaries of the frequency of angina pectoris and nitroglycerin consumption and underwent treadmill exercise testing at 2 weekly intervals. No significant differences were observed in nitroglycerin consumption or anginal frequency during these 3 treatment programs. Resting heart rates were higher with pindolol than with propranolol, but no differences were noted between periods on standard and slow-release pindolol. Systolic and diastolic blood pressures were similar during therapy with these 3 treatment programs. Treadmill walking time to the development of moderate angina and systolic and diastolic blood pressure was similar during treatment with propranolol, standard-formulation pindolol, and slow-release pindolol. Exercise heart rates were slightly higher during therapy with slow-release pindolol than during standard-formulation pindolol. It is concluded that propranolol, pindolol, and slow-release pindolol are equally effective in the management of patients with chronic, stable, exercise-induced angina.

References

Jan 1, 1974·European Journal of Clinical Pharmacology·R GuglerH J Dengler
Jun 1, 1971·Circulation·F KhajaJ O Parker
Oct 1, 1969·Circulation·S Wolfson, R Gorlin
Jan 1, 1981·European Journal of Clinical Pharmacology·W H AelligW Pacha
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss

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Citations

Jan 1, 1990·Pharmacology & Therapeutics·J McAinsh, J M Cruickshank
Mar 1, 1990·Statistics in Medicine·D R Bristol, J V Castellana

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