Comparison of sp-ICP-MS and MDG-ICP-MS for the determination of particle number concentration

Analytical and Bioanalytical Chemistry
Sabrina GschwindDetlef Günther

Abstract

In 2011, the European Commission introduced new regulations on how nanomaterials are defined. Since then, researchers have emphasized that more complete characterization of nanoparticles (NPs) includes not just mass and size determinations, but also the determination of the particle number concentrations. In this study, two different sample introduction approaches for the analysis of NP suspensions with inductively coupled plasma mass spectrometry (ICP-MS) were investigated: pneumatic nebulization (sp-ICP-MS) and microdroplet generation (MDG-ICP-MS). These approaches were compared for the determination of particle number concentrations (PNCs) of gold and silver NP suspensions diluted in either ultra-pure water or citrate solution. For accurate sp-ICP-MS analysis, it is crucial to know the transport efficiency of nebulized sample into the plasma. Here, transport efficiencies, measured by the waste collection method, were 11-14 % for Ag suspensions and 9-11 % for Au. In contrast, the droplet transport efficiency of MDG-ICP-MS was 100 %. Analysis by sp-ICP-MS yielded a lower particle number concentration than expected (only 20-40 % of the expected value), whereas MDG-ICP-MS had NP recoveries up to 80 %. This study indicates that N...Continue Reading

References

Aug 30, 2001·Scientific American·A P Alivisatos
May 19, 2009·Journal of the American Society for Mass Spectrometry·Shenghong HuXinrong Zhang
Dec 17, 2010·Environment International·Julia FabregaJamie R Lead
Jul 16, 2011·Nano Letters·Sanketh R GowdaPulickel M Ajayan
Dec 7, 2013·Analytical Chemistry·Francisco LabordaJavier Jiménez-Lamana

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Citations

Feb 15, 2019·Analytical and Bioanalytical Chemistry·Zuzana Gajdosechova, Zoltan Mester

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