Comparison of specific immunities to varicella-zoster virus following post-exposure prophylaxis of varicella by oral acyclovir observed in a family

Acta Paediatrica Japonica; Overseas Edition
Y AsanoT Yoshikawa

Abstract

An otherwise healthy 3-year-old girl developed severe varicella complicated by aseptic meningitis and received intravenous acyclovir (ACV) therapy. Her two siblings who were susceptible to varicella-zoster virus (VZV) and closely exposed to VZV in the family received oral ACV (45 or 54 mg/kg per day in four divided doses for 7 days) starting 8 days after onset of the index case for post-exposure prophylaxis of varicella. They showed only five or seven papules over the body without fever 12 days after onset of the index case, while they had one-third or half the level of antibody titer and equal sized skin reactions to VZV antigen of the index case 2.5 months later.

References

Jun 1, 1990·The Journal of Infectious Diseases·Y AsanoM Takahashi
May 29, 1969·The New England Journal of Medicine·P A BrunellB Kuo
Jan 31, 1974·The New England Journal of Medicine·A A GershonP A Brunell
May 1, 1981·The Journal of Infectious Diseases·Y AsanoT Yazaki
Feb 1, 1995·The Pediatric Infectious Disease Journal·Y C HuangC H Chiu
Aug 23, 1962·The New England Journal of Medicine·A H ROSS

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Citations

Sep 29, 2011·Pediatric Blood & Cancer·Antonio RuggieroRiccardo Riccardi

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