PMID: 3213430Jan 1, 1988Paper

Comparison of spongiform lesions in experimental scrapie and rabies in skunks

Acta Neuropathologica
A Bundza, K M Charlton

Abstract

Striped skunks were inoculated intracerebrally with the scrapie agent (suspension of brain from a naturally infected Suffolk sheep) or intramuscularly with street rabies virus (suspension of salivary glands from naturally infected skunks). Those given the scrapie agent developed clinical signs of weakness, posterior ataxia, and emaciation after incubated periods of 8 to 23 months. Those inoculated with rabies virus developed clinical signs of rabies (aggressive behavior, hyperexcitability, ataxia and paralysis) after incubation periods of 20 to 62 days. The gross lesions in the brains of the skunks given the scrapie agent consisted of marked atrophy of the thalamus and moderate atrophy of the cerebrum. No gross lesions occurred in the rabid skunks. Histologically, the type of spongiform lesion in rabies was the same as that in scrapie. However, spongiform change of rabies infected brains was less extensive (only rarely affected the basal ganglia, hippocampus or hypothalamus) than that of brains infected with the scrapie agent and was characterized by fewer numbers of small vacuoles (as a proportion of total number of vacuoles) than occurred in scrapie spongiform change.

References

Mar 1, 1986·Neuropathology and Applied Neurobiology·R H Kimberlin
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Citations

Jan 1, 1995·Micron : the International Research and Review Journal for Microscopy·M JeffreyC M Goodsir
Dec 1, 1990·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·A Bundza
Nov 24, 1999·Australian Veterinary Journal·P T HooperG J Storie
Jun 30, 2007·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Malcolm J Gains, Andrea C LeBlanc
Jun 12, 2013·Journal of Comparative Pathology·D J HicksN Johnson
May 1, 1995·Veterinary Pathology·G L Foley, J F Zachary
Feb 21, 2008·Veterinary Research·Marion Mathieson SimmonsSusan Carol Tongue

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