Comparison of Staging Systems to Assess Lymphedema Caused by Cancer Therapies, Lymphatic Filariasis, and Podoconiosis

Lymphatic Research and Biology
Janet Douglass, Louise A Kelly-Hope

Abstract

Background: Lymphedema is a disease of the skin and subcutaneous tissue resulting from a disturbance in lymph flow. Anyone can be affected, and causes include cancer therapy when lymph nodes are removed or irradiated, the parasitic disease lymphatic filariasis, and damage caused by exposure to irritant soils known as podoconiosis. Manifest lymphedema is progressive and a major contributor to disability, stigma, and social isolation for affected people. Although the pathogenesis of connective tissue changes in lymphedema will follow a similar course regardless of the disease of causation, several systems are used to stage progression. Disparity in these staging systems leads to inconsistency in reporting of the severity of lymphedema and prevents meta-analysis of research results. In the global health environment, integrated morbidity management for chronic illness is essential to meet the needs of affected people and to be sustainable for health care systems. Clinical descriptors for staging criteria within each system may assist clinicians in assessment and provide a format for consistency in reporting by lymphedema researchers. Methods and Results: Lymphedema staging systems used in oncology, filariasis, and podoconiosis s...Continue Reading

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Citations

Sep 7, 2019·Methods and Protocols·Janet DouglassLouise A Kelly-Hope
Oct 5, 2019·PLoS Neglected Tropical Diseases·Celia ZhouPhilip J Budge
Aug 23, 2020·Cancers·Melissa B AldrichEva M Sevick-Muraca
Jun 3, 2021·Journal of Clinical Medicine·Louise A Kelly-HopeMark J Taylor
Sep 11, 2021·Annals of Surgical Oncology·Yara W KassamaniAlphonse G Taghian
Nov 11, 2021·Lymphatic Research and Biology·Leigh C WardEmma Moloney

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