Comparison of standard-dose and low-dose gemcitabine regimens in pancreatic adenocarcinoma patients: a prospective randomized trial

Journal of Gastroenterology
Hiroki SakamotoMasatoshi Kudo

Abstract

A prospective, randomized study was performed to determine whether gemcitabine infusion at a low dose (250 mg/m2) is comparable or superior to the standard-dose infusion (1000 mg/m2) in terms of the survival period, clinical benefit, and frequency of adverse effects in patients with advanced pancreatic adenocarcinoma. Twenty-five patients who were histologically proven to have locally advanced pancreatic cancer or pancreatic cancer with distant metastases were initially enrolled in the present study. They were treated with gemcitabine infusion at either a dose of 1000 mg/m2 over 30 min (the standard regimen) on days 1, 8, and 15 of every 4-week cycle or at a dose of 250 mg/m2 over 30 min every week. Survival time, response rate, time to treatment failure, clinical benefit response, and adverse effects were compared between the two groups. Twenty-one patients received gemcitabine for more than 1 month. The median survival period was 7.2 months for patients who received the low-dose infusion regimen, in contrast to 5.2 months for patients administered the standard-dose infusion regimen. The time to treatment failure was 5.6 months for patients in the low-dose infusion regimen, in contrast to 3.4 months for patients in the standar...Continue Reading

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Citations

Apr 26, 2013·Cancer Chemotherapy and Pharmacology·Noboru YamamotoTomohide Tamura
Jul 10, 2013·Cancer Chemotherapy and Pharmacology·Salaheldin S HamedWilliam J Jusko
Jan 25, 2012·Antimicrobial Agents and Chemotherapy·Christine L ClouserLouis M Mansky
Jan 26, 2011·PloS One·Christine L ClouserLouis M Mansky
Sep 12, 2008·World Journal of Gastroenterology : WJG·Hisato IgarashiRyoichi Takayanagi
May 24, 2012·Toxicology and Applied Pharmacology·Cuirong ZhaoXianjun Qu
Dec 13, 2012·International Journal of Cancer. Journal International Du Cancer·Ivan ShevchenkoAlexandr V Bazhin
Mar 1, 2010·Therapeutic Advances in Medical Oncology·Ben Lawrence, Michael Findlay
Oct 15, 2010·Expert Review of Anticancer Therapy·Rizwan SheikhRay McDermott
Oct 10, 2018·AJR. American Journal of Roentgenology·Andrew B RosenkrantzGregory N Nicola
Mar 19, 2008·Molecular Cancer Therapeutics·Berta LaquenteFrancesc Viñals
Apr 2, 2021·International Journal of Pharmaceutics·Catarina OliveiraAlbino Martins
Aug 10, 2021·Oncoimmunology·Jamile Ramos da SilvaLuís Carlos de Souza Ferreira

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