Comparison of Standard Versus Wide-Field Composite Images of the Corneal Subbasal Layer by In Vivo Confocal Microscopy

Investigative Ophthalmology & Visual Science
Ahmad KheirkhahPedram Hamrah

Abstract

To evaluate whether the densities of corneal subbasal nerves and epithelial immune dendritiform cells (DCs) are comparable between a set of three representative standard images of in vivo confocal microscopy (IVCM) and the wide-field mapped composite IVCM images. This prospective, cross-sectional, and masked study included 110 eyes of 58 patients seen in a neurology clinic who underwent laser-scanning IVCM (Heidelberg Retina Tomograph 3) of the central cornea. Densities of subbasal corneal nerves and DCs were compared between the average of three representative standard images and the wide-field mapped composite images, which were reconstructed by automated mapping. There were no statistically significant differences between the average of three representative standard images (0.16 mm2 each) and the wide-field composite images (1.29 ± 0.64 mm2) in terms of mean subbasal nerve density (17.10 ± 6.10 vs. 17.17 ± 5.60 mm/mm2, respectively, P = 0.87) and mean subbasal DC density (53.2 ± 67.8 vs. 49.0 ± 54.3 cells/mm2, respectively, P = 0.43). However, there were notable differences in subbasal nerve and DC densities between these two methods in eyes with very low nerve density or very high DC density. There are no significant differ...Continue Reading

Citations

Oct 25, 2016·The Ocular Surface·Andrea CruzatPedram Hamrah
Nov 5, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Janine MikolajczakAlexander U Brandt
May 27, 2017·Journal of Microscopy·E L SchaldemoseJ R Nyengaard
Jun 14, 2019·Investigative Ophthalmology & Visual Science·Pooja KhamarSwaminathan Sethu
Dec 18, 2019·Journal of the Peripheral Nervous System : JPNS·Alexander KlitschNurcan Üçeyler
Dec 14, 2019·Eye & Contact Lens·William W BinottiPedram Hamrah
Mar 6, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Ioannis N PetropoulosRayaz A Malik
Aug 24, 2018·Diabetes & Metabolism Journal·Ioannis N PetropoulosRayaz A Malik
Nov 14, 2019·Brain Sciences·Eric A Moulton, David Borsook
Jan 7, 2021·NPJ Parkinson's Disease·Mattias AndréassonPer Svenningsson
May 14, 2021·BMC Ophthalmology·Fangting LiMingwei Zhao
May 10, 2021·Clinical Therapeutics·Ioannis N PetropoulosRayaz A Malik

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