Comparison of strain elastography, point shear wave elastography using acoustic radiation force impulse imaging and 2D-shear wave elastography for the differentiation of thyroid nodules

PloS One
Georgia KyriakidouJoerg Bojunga

Abstract

The aim of the study was to compare three different elastography methods, namely Strain Elastography (SE), Point Shear-Wave Elastography (pSWE) using Acoustic Radiation Force Impulse (ARFI)-Imaging and 2D-Shear Wave Elastography (2D-SWE), in the same study population for the differentiation of thyroid nodules. All patients received a conventional ultrasound scan, SE and 2D-SWE, and all patients except for two received ARFI-Imaging. Cytology/histology of thyroid nodules was used as a reference method. SE measures the relative stiffness within the region of interest (ROI) using the surrounding tissue as reference tissue. ARFI mechanically excites the tissue at the ROI using acoustic pulses to generate localized tissue displacements. 2D-SWE measures tissue elasticity using the velocity of many shear waves as they propagate through the tissue. 84 nodules (73 benign and 11 malignant) in 62 patients were analyzed. Sensitivity, specificity and NPV of SE were 73%, 70% and 94%, respectively. Sensitivity, specificity and NPV of ARFI and 2D-SWE were 90%, 79%, 98% and 73%, 67%, 94% respectively, using a cut-off value of 1.98m/s for ARFI and 2.65m/s (21.07kPa) for 2D-SWE. The AUROC (Area under the Receiver Operating Characteristic) of SE, A...Continue Reading

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Citations

Mar 15, 2019·Biomedical Engineering Online·Rubem P CarbenteAmauri A Assef
Mar 28, 2020·Rheumatology·Yi-Ming ChenPing-Wing Lui
Sep 3, 2020·Archives of Endocrinology and Metabolism·Hussein Hassan OkashaAbeer Awad Abdellatif
Nov 14, 2020·Clinical Hemorheology and Microcirculation·Kai-Mei Lian, Teng Lin
Apr 18, 2021·Journal of Endocrinological Investigation·K Z SwanS J Bonnema
May 26, 2021·Archives of Endocrinology and Metabolism·Hussein Hassan OkashaAbeer Awad Abdellatif

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Methods Mentioned

BETA
biopsy

Software Mentioned

ARFI
Imaging
BiAS
TIRADS

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