Comparison of stress-induced changes in noradrenergic and serotonergic neurons in the rat hippocampus using microdialysis

The European Journal of Neuroscience
A Vahabzadeh, M Fillenz

Abstract

The effects of stress on the serotonergic and noradrenergic projection to the hippocampus were compared in freely moving rats using microdialysis. Stress-induced changes in 5-hydroxytryptamine (5-HT), noradrenaline and their metabolites 5-hydroxyindoleacetic acid (5-HIAA) and 3,4-dihydroxyphenylacetic acid (DOPAC) were measured in the presence of their respective uptake blockers. Local infusion of tetrodotoxin and replacement of Ca2+ with Cd2+ were used to test dependence on impulse traffic. A 5 min tail pinch or 10 min restraint stress increased 5-HT, 5-HIAA, noradrenaline and DOPAC levels. A subcutaneous saline injection produced an increase in 5-HT and DOPAC but not noradrenaline or 5-HIAA. Although alpha 2 adrenoceptor agonists and antagonists produced changes in the baseline values of noradrenaline and DOPAC, they had little or no effect on stress-induced changes. Both the abolition of impulse traffic and its enhancement by stress had a greater effect on transmitter than on metabolite levels. Although the responses to stress of the noradrenergic and serotonergic pathway showed many similarities, there was evidence for their activation by separate pathways.

References

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Citations

Dec 29, 1995·European Journal of Pharmacology·F Bolanos-JimenezG Fillion
Nov 1, 1995·Behavioural Brain Research·M Fillenz
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Jul 28, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J P VoigtH Fink
Feb 1, 1995·The European Journal of Neuroscience·A VahabzadehM Fillenz
Mar 1, 1997·The European Journal of Neuroscience·N SingewaldA Philippu
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Keith SchutskySteven A Thomas
Jun 24, 2008·Neuropsychiatric Disease and Treatment·Frasia OosthuizenBrian H Harvey
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·G R Heninger
Jan 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Takashi YoshitakeJan Kehr
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Jan 31, 2012·Brain Research·Francisco MoraPedro Garrido
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Aug 19, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Alessandra FrigerioPasco Fearon

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