Comparison of subacute and chronic scar tissues after complete spinal cord transection

Experimental Neurology
Xing LiJianwu Dai

Abstract

Traditional views consider scar tissue formed in the lesion epicenter after severe spinal cord injury (SCI) as both a physical barrier and chemical impediment for axonal regeneration. Recently, a controversial opinion suggested that astrocyte scar formation aids rather than prevents axonal regeneration in the CNS. Here, following complete transection of the thoracic spinal cord (T8) in rats, we found that scar tissue showed greater growth factor expression at 2 weeks than 8 weeks post-SCI. Further, tandem mass tag (TMT)-based quantitative proteomic analysis revealed that the components of scar tissue formed in the subacute phase are quite different from that formed in the chronic phase. We also found significantly increased axonal regrowth of sensory axons into the lesion center after chronically formed scar tissue was removed. This indicates that scar tissue formed at the chronic phase actually inhibits axonal regeneration, and that chronic removal of scar tissue may have clinical significance and benefit for SCI repair. Taken together, our study suggests that the features and roles of subacute and chronic scar tissues formed post-SCI is different and scar tissue-targeted strategies for spinal cord regeneration cannot be gener...Continue Reading

Citations

Sep 21, 2018·Frontiers in Neuroscience·Alastair I GraingerEric J Hill
Nov 22, 2018·Frontiers in Neurology·Paulina Troncoso-EscuderoRene L Vidal
Aug 30, 2019·Nature Communications·Elizabeth J Bradbury, Emily R Burnside
Sep 19, 2019·Surgical Neurology International·Xiaoping RenSergio Canavero
Sep 5, 2020·Oxidative Medicine and Cellular Longevity·Xinyu LiBin Ning
Aug 11, 2020·Journal of Biological Engineering·Ziyuan YuZhiping Qi
Apr 23, 2020·Frontiers in Cellular Neuroscience·Tuo YangShuSen Cui
Apr 29, 2021·Neural Regeneration Research·Elliot H ChoiMichael Y Oh
Jan 19, 2021·ACS Biomaterials Science & Engineering·Lulu HuangShengwen Liu

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