PMID: 9269010Aug 1, 1997Paper

Comparison of sublingually and orally administered triazolam for premedication before oral surgery

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
C W BertholdSharon E Corey

Abstract

This study evaluated sublingual administration of triazolam for preoperative sedation in dental outpatients. A double-blind, placebo-controlled study compared 0.25 mg sublingual triazolam, 0.25 mg oral triazolam, and placebo administered 1 hour before oral surgery. Sublingual triazolam resulted in significantly less anxiety and pain at 15 minutes intraoperatively than both oral triazolam and placebo (p < 0.05). Patients' global evaluation of the efficacy of sedation ranked sublingual triazolam as significantly more efficacious than placebo (p < 0.05) with oral triazolam intermediate between the two. No difference was demonstrated in the rate of recovery or incidence of side effects between the two drug groups. Plasma triazolam levels were higher after sublingual administration during and after the surgical procedure. These results indicate that sublingual triazolam results in greater anxiolytic activity and less pain perception than oral administration as a result of greater plasma drug levels and may be useful as an alternative for nonparenteral outpatient sedation.

References

Aug 1, 1991·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S E Lieblich, B Horswell
Jan 1, 1989·Pharmacology & Toxicology·J S Schou
Oct 1, 1987·Journal of Clinical Psychopharmacology·J M ScavoneR I Shader
Mar 1, 1986·Journal of Clinical Pharmacology·J M ScavoneR I Shader
Apr 1, 1983·Journal of Clinical Psychopharmacology·D J GreenblattR I Shader
Jun 1, 1984·Journal of Dental Research·R A Dionne
Aug 1, 1995·Journal of Clinical Psychopharmacology·P D KrobothR B Smith
Nov 1, 1993·The Journal of the American Dental Association·C W BertholdR A Dionne
Feb 1, 1993·Oral Surgery, Oral Medicine, and Oral Pathology·E KaufmanR A Dionne

Citations

Sep 12, 2009·Journal of Clinical Psychopharmacology·Jacqueline E PickrellP Milgrom
Nov 21, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Paul G SimsDavid W Todd
Mar 12, 1998·The Journal of the American Dental Association·R A DionneJ C Phero
May 5, 2009·The Journal of the American Dental Association·Kazuo HosakaP Milgrom
Apr 28, 2006·The Journal of the American Dental Association·R A DionneStephen Wilson
Apr 7, 2006·Anesthesia Progress·Steven I GanzbergF Michael Beck
Jan 18, 2006·Journal of Clinical Psychopharmacology·Douglass L JacksonE D Kharasch
Jan 18, 2006·Journal of Clinical Psychopharmacology·D J Greenblatt
Jul 20, 2002·Clinical Pharmacokinetics·Hao ZhangJames B Streisand
Sep 29, 2007·Anesthesia Progress·Mark DonaldsonBrian Chanpong
Jun 2, 2001·Journal of Clinical Psychopharmacology·C M TweedyS E Coldwell
May 4, 2004·The Journal of Oral Implantology·Dennis Flanagan

Related Concepts

Anesthesia, Dental
Double-Blind Method
Sedatives
Taylor Manifest Anxiety Scale
Structure of Wisdom Tooth
Visual Analog Pain Scale
Preanesthetic Medication
Regression Analysis
Tooth Extraction
Trilam

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