PMID: 9269010Aug 1, 1997Paper

Comparison of sublingually and orally administered triazolam for premedication before oral surgery

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
C W BertholdSharon E Corey


This study evaluated sublingual administration of triazolam for preoperative sedation in dental outpatients. A double-blind, placebo-controlled study compared 0.25 mg sublingual triazolam, 0.25 mg oral triazolam, and placebo administered 1 hour before oral surgery. Sublingual triazolam resulted in significantly less anxiety and pain at 15 minutes intraoperatively than both oral triazolam and placebo (p < 0.05). Patients' global evaluation of the efficacy of sedation ranked sublingual triazolam as significantly more efficacious than placebo (p < 0.05) with oral triazolam intermediate between the two. No difference was demonstrated in the rate of recovery or incidence of side effects between the two drug groups. Plasma triazolam levels were higher after sublingual administration during and after the surgical procedure. These results indicate that sublingual triazolam results in greater anxiolytic activity and less pain perception than oral administration as a result of greater plasma drug levels and may be useful as an alternative for nonparenteral outpatient sedation.


Aug 1, 1991·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S E Lieblich, B Horswell
Jan 1, 1989·Pharmacology & Toxicology·J S Schou
Oct 1, 1987·Journal of Clinical Psychopharmacology·J M ScavoneR I Shader
Mar 1, 1986·Journal of Clinical Pharmacology·J M ScavoneR I Shader
Apr 1, 1983·Journal of Clinical Psychopharmacology·D J GreenblattR I Shader
Jun 1, 1984·Journal of Dental Research·R A Dionne
Aug 1, 1995·Journal of Clinical Psychopharmacology·P D KrobothR B Smith
Nov 1, 1993·The Journal of the American Dental Association·C W BertholdR A Dionne
Feb 1, 1993·Oral Surgery, Oral Medicine, and Oral Pathology·E KaufmanR A Dionne


Sep 12, 2009·Journal of Clinical Psychopharmacology·Jacqueline E PickrellP Milgrom
Nov 21, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Paul G SimsDavid W Todd
Mar 12, 1998·The Journal of the American Dental Association·R A DionneJ C Phero
May 5, 2009·The Journal of the American Dental Association·Kazuo HosakaP Milgrom
Apr 28, 2006·The Journal of the American Dental Association·R A DionneStephen Wilson
Apr 7, 2006·Anesthesia Progress·Steven I GanzbergF Michael Beck
Jan 18, 2006·Journal of Clinical Psychopharmacology·Douglass L JacksonE D Kharasch
Jan 18, 2006·Journal of Clinical Psychopharmacology·D J Greenblatt
Jul 20, 2002·Clinical Pharmacokinetics·Hao ZhangJames B Streisand
Sep 29, 2007·Anesthesia Progress·Mark DonaldsonBrian Chanpong
Jun 2, 2001·Journal of Clinical Psychopharmacology·C M TweedyS E Coldwell
May 4, 2004·The Journal of Oral Implantology·Dennis Flanagan

Related Concepts

Anesthesia, Dental
Double-Blind Method
Taylor Manifest Anxiety Scale
Structure of Wisdom Tooth
Visual Analog Pain Scale
Preanesthetic Medication
Regression Analysis
Tooth Extraction

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.