PMID: 2105052Jan 1, 1990Paper

Comparison of substrate utilization by indirect calorimetry during cyclic and continuous total parenteral nutrition

The American Journal of Clinical Nutrition
B JustE Camillo

Abstract

Five male adult home patients were studied in a randomized order under continuous (24 h/d) and nocturnal cyclic (15 h/d) isocaloric, isonitrogenous total parenteral nutrition (TPN). They received 2626 +/- 265 total kcal/d as 60% dextrose and 40% lipids; the 3-h lipid infusion was followed by the dextrose amino acid infusion on both regimens. Substrate oxidation was measured by indirect calorimetry during four periods on the fourth day of each regimen. During cyclic TPN net lipogenesis occurred with a nonproteic respiratory quotient (npRQ) greater than 1 during dextrose amino acid infusion followed by net lipolysis with an npRQ less than 1 during the nonnourishing phase. In contrast, during continuous TPN net lipogenesis persisted with an npRQ greater than 1 over the 21 h of dextrose amino acid infusion. During the 3-h lipid infusion, fat oxidation was observed during both regimens but was more pronounced during cyclic TPN (p less than 0.05). As a consequence, 24-h lipid oxidation was higher and 24-h dextrose utilization lower during cyclic vs continuous TPN (p less than 0.05). These results suggest that cyclic TPN when alternating between substrate storage and oxidation, mimics the physiological pattern of oral feeding.

Citations

Apr 1, 1994·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·A Hyltander
Apr 13, 2004·Journal of Pediatric Gastroenterology and Nutrition·Olivier GouletVirginie Colomb
Sep 23, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Jeffrey Rothschild, William Lagakos
Mar 4, 2003·Pediatric Research·Laurent BéghinFrédéric Gottrand
Mar 10, 2012·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Sreenija SuryadevaraEzra Steiger
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J Galgani, E Ravussin
Jun 29, 2010·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Stephen Marc Stout, M Petrea Cober
Jul 19, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Sandra I AusthofDonald F Kirby
Oct 11, 2013·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·T Hang Nghiem-RaoPraveen S Goday
Apr 1, 1994·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·L M Gramlich
Aug 18, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Manpreet S MundiSara Bonnes
Oct 2, 2014·Journal of Pediatric Gastroenterology and Nutrition·Florence LacailleRaanan Shamir
Oct 6, 2017·Nutrition Journal·Jose J Arenas VillafrancaJimena Abilés
Dec 1, 1992·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·K KhanM Elia
Feb 1, 1995·Metabolism: Clinical and Experimental·P J JonesR A Pederson
Jun 1, 1997·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·B FrançoisC Ricour
Mar 1, 1997·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A G Dulloo

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