PMID: 41521Aug 15, 1979

Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals

The Biochemical Journal
C C Winterbourn

Abstract

Iron--EDTA was shown to catalyse OH. production from H2O2 and ascorbate by a mechanism largely independent of superoxide. When ascorbate and superoxide were both present, the ascorbate mechanism was more important than superoxide as a source of OH., and would appear to be more significantly biologically.

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