Comparison of Survival Benefits of Combined Chemotherapy and Radiotherapy Versus Chemotherapy Alone for Uterine Serous Carcinoma: A Meta-analysis

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Yanying LinJianliu Wang

Abstract

To date, there is no convincing evidence comparing the impact of combined chemotherapy and radiotherapy with chemotherapy alone in postoperative uterine serous carcinoma (USC), which remains an unclear issue. We conducted a meta-analysis assessing the impact of combined chemotherapy and radiotherapy compared to chemotherapy alone on overall survival in postoperative USC. A comprehensive search was performed in the databases of EMBASE, PubMed, Web of Science, and Cochrane Library from inception to March 2016. Studies comparing survival among patients who underwent combined chemotherapy and radiotherapy or chemotherapy alone after surgery for USC were included. Quality assessments were carried out by the Newcastle-Ottawa Scale. Hazard ratio (HR) for overall survival was extracted, and a random-effects model was used for pooled analysis. Publication bias was assessed using both funnel plot and the Egger regression test. Statistical analyses were performed using Stata version 13.0 software. Nine retrospective studies with relatively high quality containing 9354 patients were included for the final meta-analysis. The pooled results demonstrated that combined chemotherapy and radiotherapy significantly reduced the risk of death (HR, ...Continue Reading

References

Jun 22, 2000·The New England Journal of Medicine·J ConcatoR I Horwitz
Aug 12, 2003·International Journal of Radiation Oncology, Biology, Physics·Brij M SoodB Vikram
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Apr 7, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·William Creasman
Aug 10, 2010·Gynecologic Oncology·J Alejandro Rauh-HainMarcela G del Carmen
Sep 25, 2012·Gynecologic Oncology·Marcela G del CarmenJohn O Schorge
Jul 3, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Hyun Jong ParkYoung Tae Kim
Oct 25, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Satoru SagaeWilliam Small

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Citations

Apr 9, 2020·Journal of Gynecologic Oncology·Jessie Y LiShari Damast
Dec 29, 2017·Advanced Healthcare Materials·Antonia G DenkovaPablo Serra-Crespo

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Software Mentioned

Stata
ITC
Engauge Digitiser

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