Comparison of sustained-release and rapid-release β-alanine formulations on changes in skeletal muscle carnosine and histidine content and isometric performance following a muscle-damaging protocol

Amino Acids
Alyssa N VaranoskeJeffrey R Stout

Abstract

β-alanine supplementation increases muscle carnosine content and improves anaerobic exercise performance by enhancing intracellular buffering capacity. β-alanine ingestion in its traditional rapid-release formulation (RR) is associated with the symptoms of paresthesia. A sustained-release formulation (SR) of β-alanine has been shown to circumvent paresthesia and extend the period of supply to muscle for carnosine synthesis. The purpose of this investigation was to compare 28 days of SR and RR formulations of β-alanine (6 g day-1) on changes in carnosine content of the vastus lateralis and muscle fatigue. Thirty-nine recreationally active men and women were assigned to one of the three groups: SR, RR, or placebo (PLA). Participants supplementing with SR and RR formulations increased muscle carnosine content by 50.1% (3.87 mmol kg-1ww) and 37.9% (2.62 mmol kg-1ww), respectively. The change in muscle carnosine content in participants consuming SR was significantly different (p = 0.010) from those consuming PLA, but no significant difference was noted between RR and PLA (p = 0.077). Although participants ingesting SR experienced a 16.4% greater increase in muscle carnosine than RR, fatigue during maximal voluntary isometric contrac...Continue Reading

References

Aug 1, 1972·Journal of Applied Physiology·B AhlborgL O Nordesjö
Feb 5, 2000·Equine Veterinary Journal. Supplement·M Dunnett, R C Harris
Nov 8, 2002·The Journal of Nutrition·Wantanee KriengsinyosPaul B Pencharz
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert A CrozierMark H Pausch
May 18, 2007·Journal of Agricultural and Food Chemistry·Leticia MoraFidel Toldrá
Nov 11, 2008·Journal of the International Society of Sports Nutrition·Jeffrey R StoutRoger C Harris
Jul 31, 2010·Journal of Applied Physiology·Audrey BaguetWim Derave
Dec 6, 2011·Amino Acids·Jacques DécombazTrent Stellingwerff
Jun 16, 2012·Journal of the International Society of Sports Nutrition·Craig SaleRoger C Harris
Jul 17, 2012·Journal of Strength and Conditioning Research·Abbie E Smith-RyanKristina L Kendall
Sep 15, 2012·Public Health Nutrition·Philip W J Harvey, Omar Dary
Feb 27, 2013·Medicine and Science in Sports and Exercise·Sanne StegenWim Derave
May 15, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Vitor de Salles PainelliGuilherme Giannini Artioli
Apr 11, 2014·Journal of the International Society of Sports Nutrition·Jay R HoffmanIshay Ostfeld
Sep 24, 2014·Pharmacological Reviews·Michael BaderRobson A Santos
Jul 25, 2015·Amino Acids·Jay R HoffmanDaniel S Moran
Sep 17, 2015·Medicine and Science in Sports and Exercise·Jeremy R TownsendJeffrey R Stout
Nov 1, 2016·British Journal of Sports Medicine·Bryan SaundersBruno Gualano
Jan 21, 2017·Medicine and Science in Sports and Exercise·Laura BlancquaertWim Derave
Mar 30, 2017·European Journal of Applied Physiology·Rebecca Louise JonesCraig Sale
Sep 15, 2017·Journal of the American College of Nutrition·David D ChurchJeffrey R Stout
Mar 21, 2018·Advances in Food and Nutrition Research·Jay R HoffmanJeffrey R Stout
Sep 14, 2018·Amino Acids·Dmitry Spelnikov, Roger Charles Harris

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Citations

Dec 20, 2018·Journal of the International Society of Sports Nutrition·Liam BeasleyJustin Roberts
Jan 9, 2019·Amino Acids·Wim DeraveShahid P Baba
Dec 16, 2018·European Journal of Nutrition·Bryan SaundersBruno Gualano
Sep 14, 2018·Amino Acids·Dmitry Spelnikov, Roger Charles Harris
Sep 12, 2019·Frontiers in Nutrition·Pedro PerimBryan Saunders
May 15, 2019·Medicine and Science in Sports and Exercise·Joseph J MatthewsCraig Sale
Nov 16, 2018·Journal of Strength and Conditioning Research·Gabriel M P Brisola, Alessandro M Zagatto
Apr 3, 2021·Journal of the International Society of Sports Nutrition·Kealey J WohlgemuthAbbie E Smith-Ryan

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SPSS
FoodWorks Dietary Analysis
Power
MATLAB

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