Comparison of swallowing function in Parkinson's disease and progressive supranuclear palsy

Movement Disorders : Official Journal of the Movement Disorder Society
B T JohnstonD O Castell

Abstract

Dysphagia is common in both Parkinson's disease (PD) and progressive supranuclear palsy (PSP). Although it is believed to be more common in PSP, there are no controlled data and no comparison of swallowing function between these two disorders. Our aim was to assess dysphagia and swallow function in patients with PSP and PD. Seven patients with PSP were matched to seven patients with PD on the basis of disease duration. Self-rated dysphagia, movement disorder disability, modified barium swallow results, and abnormalities noted on manometry of the lower esophageal sphincter, esophageal body, upper esophageal sphincter, and pharynx were compared between the two groups. Neither severity nor duration of dysphagia differed between the two groups. Patients with PSP had a significantly greater degree of disability [median (range) Hoehn & Yahr score, 4 (3-5) vs. 2 (1-2); P < 0.002]. Manometric abnormalities were similar for the two groups. Oral-phase abnormalities on modified barium swallow were significantly more frequent in PSP (four patients with PSP vs. no patients with PD; p < 0.005). Pharyngeal abnormalities did not differ. Modified barium-swallow scores correlated well with self-reported dysphagia severity for patients with PSP (...Continue Reading

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Citations

Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Cumhur ErtekinFigen Esmeli
Jan 1, 1996·Dysphagia·D W Buchholz
Nov 2, 2014·Journal of Movement Disorders·Cumhur Ertekin
Oct 21, 2016·American Journal of Alzheimer's Disease and Other Dementias·Gabriele CiprianiAngelo Nuti
Dec 15, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Nicholas J CordatoJohn G L Morris
Aug 18, 2016·JBI Database of Systematic Reviews and Implementation Reports·Erica TilleyMicah D J Peters
Nov 5, 2019·Dysphagia·Heather M ClarkKeith A Josephs
Oct 27, 2018·Movement Disorders Clinical Practice·Inga ClausTobias Warnecke
Sep 21, 2018·Current Neurology and Neuroscience Reports·Karoline Knudsen, Per Borghammer
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Tobias WarneckeRainer Dziewas
Jun 27, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·James C BordersMichelle S Troche
Aug 25, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Heather M ClarkJennifer L Whitwell
Nov 14, 2018·Dementia and Geriatric Cognitive Disorders·Courtney LewisAdam P Vogel

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