Comparison of Syndecan-1 Immunohistochemical Expression in Lobular and Ductal Breast Carcinoma with Nodal Metastases

Analytical Cellular Pathology (Amsterdam)
Ivana Miše, Majda Vučić

Abstract

Syndecan-1 (Sdc1) is a transmembrane heparan sulfate proteoglycan, an extracellular matrix receptor involved in intercellular communication, proliferation, angiogenesis, and metastasis. This study determined and compared Sdc1 expression in the tumor cells and stroma of 30 invasive lobular and 30 invasive ductal breast carcinomas (ILCs/IDCs), also in the axillary node metastases of ductal type, and correlated it with clinical and tumor parameters. Sdc1 was expressed in the epithelium of 90% carcinoma of both histological types. Also, it was most frequently expressed in their tumor stroma, but in ILC, stromal expression was negative in 40%. Sdc1 was expressed in 86.7% of the metastatic epithelium of IDC nodal metastases (in even 50% as high expression), while the nodal stroma was negative in 46.7%. Primary IDC showed a negative correlation between epithelial Sdc1 and progesterone receptors (PRs), whereas ILC showed a positive correlation between stromal Sdc1 and histological gradus. In the metastatic epithelium, Sdc1 was negatively correlated with a patient's age, estrogen receptors (ERs), and PRs in the primary tumors, while the stroma of metastases demonstrated a positive correlation with the focus number in primary tumors and ...Continue Reading

References

Oct 1, 1992·The Journal of Investigative Dermatology·R D SandersonM Bernfield
Oct 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K HayashiM Bernfield
Jun 15, 1996·Journal of Cellular Biochemistry·J R Couchman, A Woods
Feb 1, 1996·Annals of Medicine·P Inki, M Jalkanen
Sep 9, 1999·American Journal of Clinical Pathology·M J StanleyR Zera
Mar 15, 2000·The International Journal of Biochemistry & Cell Biology·S TumovaJ R Couchman
Jun 29, 2000·Annual Review of Biochemistry·M BernfieldM Zako
Jun 8, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A AnttonenH Joensuu
Apr 1, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martin Götte
Jun 5, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Brandon J BurbachAlan C Rapraeger
Jul 23, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Anu AnttonenHeikki Joensuu
Aug 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Perkins MukunyadziChun-Yang Fan
Jan 9, 2004·Reproductive Biology and Endocrinology : RB&E·DeannaLee M Beauvais, Alan C Rapraeger
Jun 5, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D MennerichA Sommer
Oct 2, 2004·Oncology·Marja LeivonenCaj Haglund
Dec 18, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Anita L BaneFrances P O'Malley
Feb 2, 2006·CA: a Cancer Journal for Clinicians·S Eva Singletary, James L Connolly
Feb 14, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C C LopesH B Nader
Mar 25, 2006·Journal of Cancer Research and Clinical Oncology·A AnttonenH Joensuu
Mar 10, 2007·The Journal of Biological Chemistry·Yang YangRalph D Sanderson
Apr 25, 2007·International Journal of Cancer. Journal International Du Cancer·Dong Soon ChoiChurl K Min
Jun 15, 2007·Pathology·Marcello GuarinoGianmario Ballabio
Oct 10, 2007·Biochemistry. Biokhimii︠a︡·T Yu EshchenkoE V Grigorieva
Jun 11, 2008·British Journal of Cancer·D LoussouarnM Campone
May 29, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A MartínezI G Rojas
Jul 15, 2009·The Journal of Biological Chemistry·Yekaterina B KhotskayaRalph D Sanderson
Oct 29, 2009·Cancer Science·Keiji ShimadaNoboru Konishi
Oct 15, 2011·Journal of Gynecologic Oncology·Yu Im KimSu Young Kim
Apr 5, 2013·International Journal of Clinical Oncology·Sung Hak LeeChang Suk Kang
Oct 3, 2013·BMC Cancer·Eloah Rabello SuarezMaria Aparecida Silva Pinhal
Oct 24, 2013·Histology and Histopathology·Marina PalaiologouDina Tiniakos

❮ Previous
Next ❯

Citations

May 11, 2020·Pathology Oncology Research : POR·Katalin KarásziIlona Kovalszky

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS Statistics

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.