PMID: 9536290Apr 16, 1998Paper

Comparison of synovial fluid cartilage marker concentrations and chondral damage assessed arthroscopically in acute knee injury

Osteoarthritis and Cartilage
A E BelloV B Kraus

Abstract

To examine the correlation between synovial fluid cartilage markers and degree of cartilage damage determined by arthroscopic evaluation in subjects with acute knee injury. Chondral damage was quantified using a validated arthroscopic scoring system in 20 subjects with effusive acute knee injuries of less then 4 months duration and no history or radiographic evidence of joint pathology. Levels of synovial fluid 3B3(-) neoepitope, 3B3(+) chondroitinase generated epitope of proteoglycan, keratan sulfate (KS) and hyaluronic acid (HA) were measured by competitive enzyme-linked immunosorbent assays using monoclonal antibodies 3B3 and 5D4. Total sulfated glycosaminoglycan (GAG) was measured by 1,9-dimethylmethylene blue colorimetric dye-binding assay. We found a dramatic decrease in levels of 3B3(-) (rs = -0.62, P = 0.004), and GAG (rs = -0.49, P = 0.03) with increasing chondral damage score; but no correlation of damage score with 3B3(+), KS or HA levels. These data reveal a change in cartilage metabolism within the first 4 months of symptomatic knee injury evinced by a significant inverse correlation of 3B3(-) and GAG levels to chondral lesion severity. These results suggest that serial measurement of these synovial fluid markers i...Continue Reading

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Citations

Dec 17, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Mehmet Hakan OzsoyArzu Ozsoy
Feb 21, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Cathy S CarlsonVirginia B Kraus
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Douglas J WylandThomas P Vail
Apr 29, 1998·Journal of Women's Health
Aug 16, 2014·Biomarkers in Medicine·Anne S SiebuhrAnne C Bay-Jensen
Mar 4, 2008·Arthritis and Rheumatism·Benjamin D WardSteven A Olson
Jun 10, 2008·Osteoarthritis and Cartilage·D R SeiferV Byers Kraus
May 18, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·E LindhorstV B Kraus
Aug 9, 2005·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Graham Tytherleigh-StrongAnthony Miniaci
Jan 19, 2002·Research in Veterinary Science·M ViitanenS May
Jun 5, 1999·Rheumatic Diseases Clinics of North America·F A Wollheim

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