Comparison of systemic and renal effects of dopexamine and dopamine in norepinephrine-treated septic shock

Journal of Cardiothoracic and Vascular Anesthesia
Martin SchmoelzMichael Irlbeck

Abstract

Vasopressor-induced vasoconstriction may compromise renal and splanchnic blood flow in patients with septic shock, resulting in secondary organ failures. The authors compared the effects of the vasodilatatory agent dopexamine against renal-dose dopamine and placebo in patients with norepinephrine therapy and septic shock, using 24-hour serum creatinine clearance (C(crea)) as a major endpoint. The primary hypothesis to be tested was that dopexamine is more effective than dopamine and that dopamine shows better effects than placebo regarding organ failures and C(crea). A prospective, randomized, controlled, double-blinded study. Intensive care unit in a tertiary care university hospital. Sixty-one patients with septic shock defined according to established criteria. Patients received either dopexamine (2 microg/kg/min, n = 20), dopamine (3 microg/kg/min, n = 21), or placebo (n = 20). The trial groups were similar in terms of baseline characteristics. The authors found no significant differences among the dopexamine, dopamine, and placebo groups with regard to a comprehensive number of renal function parameters including C(crea) and organ-failure scores. There was a significant increase in heart rate after dopexamine infusion; oth...Continue Reading

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Mar 25, 2014·Heart Failure Clinics·Claudio Ronco, Luca Di Lullo
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Jan 11, 2012·Nursing in Critical Care·Andrew Parry
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May 16, 2019·Critical Care : the Official Journal of the Critical Care Forum·Lu ChengJun Lu

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