Comparison of systemic mycophenolate mofetil with topical clobetasol in lichen planopilaris: a parallel-group, assessor- and analyst-blinded, randomized controlled trial

American Journal of Clinical Dermatology
Vahide LajevardiSara Beygi

Abstract

Lichen planopilaris (LPP) is the most common cause of inflammatory immune-mediated cicatricial alopecia. If not diagnosed and treated properly, it may lead to irreversible hair loss with a devastating impact on quality of life. However, treatment can be a challenge. In an area lacking these sorts of studies, we conducted a randomized controlled trial (RCT) to study the tolerability and therapeutic effects of topical clobetasol versus systemic mycophenolate mofetil (MMF). A randomized, assessor- and analyst-blinded controlled trial was conducted in 60 patients with LPP in Razi Dermatology Hospital, Tehran, Iran, between February and December 2013. Patients were treated with clobetasol lotion 0.05 % applied at night or oral MMF 2 g/day and were followed for 6 months. The Lichen Planopilaris Activity Index (LPPAI) was the primary measure of response to treatment. Systemic MMF and topical clobetasol were equally effective in reducing the LPPAI over 6 months of treatment. Treatment tolerability was excellent in both groups and no serious irreversible adverse effects were detected. Satisfaction with treatment rose in the MMF group over time; however, it declined in the clobetasol group. Given the similar efficacy profiles, topical cl...Continue Reading

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Citations

Dec 22, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·C MathesU F Schaefer
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Feb 14, 2021·Dermatologic Therapy·Farahnaz Fatemi NaeiniFatemeh Mohaghegh
Apr 20, 2021·Indian Journal of Dermatology, Venereology and Leprology·Farahnaz Fatemi NaeiniGita Faghihi

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