PMID: 8938851Nov 1, 1996Paper

Comparison of T-cell subpopulations in cats naturally infected with feline leukaemia virus or feline immunodeficiency virus

Research in Veterinary Science
G Hoffmann-FezerW Kraft

Abstract

T-cell subsets were studied by flow cytometry in 58 feline leukaemia virus (FeLV)-positive cats with naturally acquired FeLV infection to determine whether the changes in CD4+ or CD8+ T cell populations differed from those observed in 55 feline immunodeficiency virus (FIV)-positive cats with naturally acquired FIV infection. The sole criterion for inclusion into the study was seropositivity. Mean (SD) CD4+ T cell values of FeLV positive cats were decreased to 31.1 (8.0) per cent and their CD8+ T cell values were increased to 22.8 (6.3) per cent in comparison with uninfected control cats (37.9 [9.5] per cent CD4+; 15.2 [6.3] per cent CD8+). The CD4+/CD8+ ratio was reduced to 1.5 (0.7), compared with 3.0 (1.5) in 39 FeLV-and FIV-negative control cats. Differences from control values were significant, but there was no significant difference between CD4+ and CD8+ lymphocytes of FeLV-versus FIV-infected cats. These findings indicate that FeLV and FIV have similar effects on T lymphocyte subsets. Both retrovirus infections can induce immunodeficiency, both viruses infect a broad range of lymphohaemopoietic cells, despite having different primary target cells, and can induce the killing of lymphocytic cells in vitro. It is concluded t...Continue Reading

Citations

Dec 5, 1998·Veterinary Immunology and Immunopathology·S PaltrinieriS Comazzi
Oct 30, 2003·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Cornelia J Ketz-RileyMichael T Barrie
Dec 4, 2012·Viruses·Katrin Hartmann
Sep 21, 2015·Comparative Immunology, Microbiology and Infectious Diseases·Michèle BergmannKatrin Hartmann
Jan 10, 2020·Journal of Feline Medicine and Surgery·Susan LittleKelly St Denis

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