PMID: 1206124Dec 1, 1975Paper

Comparison of tablets and paper discs for antibiotic sensitivity testing

Journal of Clinical Pathology
D F Brown, D Kothari

Abstract

The value of tablets and paper discs as reservoirs of antimicrobial agents for use in sensitivity testing was compared. Antibiotics that were unstable in paper discs showed no demonstrable loss of activity in tablets over a period of 50 days under adverse storage conditions. The antibiotic content of commercially prepared tablets is very high in comparison with the accepted content of paper discs used in Britain, but not all of the agent is released from tablets during tests. Comparison of the size of zones of inhibition around tablets and standard paper discs indicated that the amount of the various agents released from the tablets varied between 2-6% and 69% of the stated content. In tests of the sensitivity of a range of common pathogenic organisms, the results obtained with the tablet method--when interpreted as recommended by the manufacturer--were generally similar to those obtained with a paper disc method commonly used in British laboratories. In 47% of tests with aminoglycoside antibiotics, however, strains sensitive by the disc method were 'intermediate' or resistant by the tablet method. As with paper discs, it was necessary to press the tablets on to the medium. With adjustment of the 'effective antibiotic content o...Continue Reading

References

Jan 1, 1973·Acta Clinica Belgica·O Gylling Pedersen
Aug 1, 1966·Canadian Journal of Microbiology·P Chadwick, D E Mahony

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Citations

Sep 1, 1978·Journal of Clinical Pathology·D J Flowers
Jul 1, 1979·Journal of Clinical Pathology·J B Casals
Nov 1, 1975·British Journal of Industrial Medicine·J R Jagoe, K A Paton
Oct 28, 2019·International Journal of Systematic and Evolutionary Microbiology·Dhiraj Kumar ChaudharyJaisoo Kim
Mar 2, 2021·Systematic and Applied Microbiology·Izzet Burcin SaticiogluNevzat Sahin
Jul 24, 2021·International Journal of Systematic and Evolutionary Microbiology·Muhammed DumanIzzet Burcin Saticioglu
Sep 14, 2021·Archives of Microbiology·Izzet Burcin Saticioglu

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