Comparison of the 1-gram [14C]xylose, 10-gram lactulose-H2, and 80-gram glucose-H2 breath tests in patients with small intestine bacterial overgrowth

Gastroenterology
C E King, Phillip P Toskes

Abstract

The sensitivity of three breath tests (1-g [14C]xylose, 10-g lactulose-H2, and 80-g glucose-H2) was studied in 20 subjects with culture-documented small intestine bacterial overgrowth. Elevated breath 14CO2 levels were seen within 30 min of [14C]xylose administration in 19 of 20 subjects with bacterial overgrowth and 0 of 10 controls. In contrast, H2 breath tests demonstrated uninterpretable tests (absence of H2-generating bacteria) in 2 of 20 subjects with bacterial overgrowth and 1 of 10 controls and nondiagnostic increases in H2 production in 3 of 18 glucose-H2 and 7 of 18 lactulose-H2 breath tests in subjects with bacterial overgrowth. These findings demonstrate continued excellent reliability of the 1-g [14C]xylose breath test as a diagnostic test for bacterial overgrowth, indicate inadequate sensitivity of H2 breath tests in detecting bacterial overgrowth, and suggest the need for evaluation of a 13CO2 breath test having the same characteristics as the [14C]xylose test (avidly absorbed substrate having minimal contact with the colonic flora) for nonradioactive breath detection of bacterial overgrowth in children and reproductive-age women.

Citations

Jan 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·P P Purdum, D F Kirby
Sep 9, 1999·Journal of Clinical Gastroenterology·R M Craig, E D Ehrenpreis
May 21, 2003·Alimentary Pharmacology & Therapeutics·F PerriSergio Vigneri
Jul 9, 2008·Scandinavian Journal of Gastroenterology·S V Rana, S B Bhardwaj
Oct 15, 2008·Arquivos De Gastroenterologia·Wellington Monteiro MachadoCarlos Roberto Padovani
Oct 17, 2014·World Journal of Gastroenterology : WJG·Cristina Sánchez-MontesPilar Nos
Mar 23, 2017·The American Journal of Gastroenterology·Ali RezaieMark Pimentel
Feb 13, 2018·Journal of Neurogastroenterology and Motility·Kee Wook JungSeung-Jae Myung
Mar 22, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Francisco Domper BardajíJesús Martín Fernández
Nov 1, 1991·International Journal of Colorectal Disease·J Santavirta
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·S M Riordan, T D Bolin
Nov 21, 1991·The New England Journal of Medicine·H C SoudahC Owyang
Jun 1, 1989·Digestive Diseases and Sciences·P R HoltR M Russell
Oct 29, 2000·The American Journal of Gastroenterology·S M RiordanT D Bolin
Jul 29, 2000·Journal of Clinical Gastroenterology·F CastiglioneG Mazzacca
May 22, 2003·Journal of the American Geriatrics Society·Alexandr ParlesakChristiane Bode
Oct 22, 2008·Journal of Clinical Gastroenterology·John G Lieb, Peter V Draganov
Nov 9, 2007·Digestive Diseases and Sciences·Reza KhoshiniMark Pimentel
Feb 13, 2009·Expert Review of Gastroenterology & Hepatology·Ahmed Abu-Shanab, Eamonn Mm Quigley
Mar 15, 2011·Alimentary Pharmacology & Therapeutics·R S ChoungY A Saito
May 1, 1992·Scandinavian Journal of Gastroenterology·E Husebye, K Engedal
Apr 1, 1995·Journal of Internal Medicine·E Husebye
Jan 11, 2001·The American Journal of Gastroenterology·M PimentelH C Lin
Jul 10, 2004·Journal of Gastroenterology and Hepatology·Marcus TeoAdrian Cummins
Jul 22, 2005·European Journal of Clinical Nutrition·K D Wutzke, I Oetjens
Oct 12, 2012·Digestive Diseases and Sciences·Nina S GeorgeHenry P Parkman
Nov 10, 2007·Current Gastroenterology Reports·Lawrence R Schiller
Jul 26, 2016·Canadian Journal of Gastroenterology & Hepatology·Amelie TherrienMickael Bouin
Feb 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·K EinarssonI Björkhem
Aug 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·S F DellertJ E Heubi
Mar 26, 2004·European Journal of Clinical Nutrition·K D Wutzke, B Glasenapp
Jan 16, 2004·Current Treatment Options in Gastroenterology·Virmeet V. Singh, Phillip P. Toskes
Mar 29, 2008·The American Journal of Gastroenterology·Jason R BrattenMichael P Jones
Sep 10, 2003·Current Gastroenterology Reports·Virmeet V Singh, Phillip P Toskes
Sep 3, 2013·Therapeutic Advances in Chronic Disease·Amit H Sachdev, Mark Pimentel
Nov 20, 2019·Journal of Neurogastroenterology and Motility·Giuseppe LosurdoAlfredo Di Leo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.