Abstract
The antiviral activity and induction of interferon-like substance by mepacrine (quinacrine, Atabrine) and Acranil in mice, described previuosly, was studied in more detail and compared with tilorone. The serum substance induced by Acranil was characterized as mouse interferon. Acranil, given parenterally, proved to be as strong as tilorone regarding interferon stimulation, in spite of the presence of only one side chain in the Acrainl molecule. Mepacrine was found to be a wealer interferon inducer than either tilorone or Acranil. The mode of interferon induction by Acranil and tilorone (effect of metabolic inhibitors, hyporesponsiveness to repeated doses, correlation between acute toxicity and antiviral activity, failure of effectiveness in chicks and chicken embryo tissue culture) was found comparable. However, the body temperature reactions of mice to the drugs were different: a striking hypothermic effect of tilorone, a lower one of mepacrine and the absence of body temperature depression by Acranil was observed.
References
Sep 18, 1970·Science·R E Krueger, G D Mayer
Nov 1, 1970·Virology·E De Clercq, T C Merigan
Mar 1, 1973·Journal of Medicinal Chemistry·A D SillF W Sweet
Mar 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·R L SoehnerM Pollard
Aug 1, 1974·Journal of Medicinal Chemistry·E R AndrewsG D Mayer
Aug 1, 1974·Journal of Medicinal Chemistry·W L AlbrechtG D Mayer
Aug 1, 1974·Journal of Medicinal Chemistry·J M GrisarG D Mayer
Jan 1, 1972·Antimicrobial Agents and Chemotherapy·D J GironF F Pindak
May 1, 1973·Antimicrobial Agents and Chemotherapy·E T GlázM Tálas
Jun 1, 1973·Antimicrobial Agents and Chemotherapy·P SiminoffK E Price
Jan 1, 1971·Annual Review of Microbiology·C Colby, M J Morgan
Dec 1, 1971·The Journal of Infectious Diseases·J Portnoy, T C Merigan
Sep 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·Y H TanM Ho
Jul 1, 1970·Archives of Internal Medicine·E De Clercq, T C Merigan
Dec 1, 1965·Virology·J S YoungnerS E Taube
Citations
Jan 1, 1979·Neuroscience and Biobehavioral Reviews·W G Clark
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·W G Clark, Y L Clark
Jan 1, 1981·Pharmacology & Therapeutics·W Regelson
May 1, 1982·Medical Hypotheses·D AderkaJ Pinkhas
May 31, 2011·Antiviral Research·Michele TonelliPaolo La Colla
Feb 1, 1991·Cytotechnology·G FiorucciG B Rossi
Jun 1, 1977·Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology·M Degré, E T Gláz
Feb 1, 1985·Cellular Immunology·T SaitoM A Chirigos