Comparison of the Accuracy of DWI and Ultrasonography in Screening Hepatocellular Carcinoma in Patients With Chronic Liver Disease

Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society
Reza JalliKourosh Kazemi

Abstract

Hepatocellular carcinoma (HCC) is a neoplasm usually arising in a cirrhotic liver by a multistep carcinogenesis process. Early detection of HCC and accurate assessment of tumor burden are crucial to successful treatment planning and long-term survival. In this study, we compared the accuracy of diffusion weighted imaging (DWI) combined with limited sequence magnetic resonance imaging (MRI) set as a potentially quick and practical MR candidate with ultrasonography (US) for screening of HCC in patients with cirrhosis. Of 96 patients with cirrhosis, 30 who had concomitant HCC proved by pathology were selected. MRI, DWI, and US of the liver were performed for the patients. Sensitivity, specificity, and accuracy of DWI alone, limited sequences MRI alone, a combination of them, and US were calculated for the detection of HCC in these patients and then comparison between these modalities was performed. Combination of limited sequences MRI and DWI had the highest accuracy (94.79%) followed by DWI alone followed by limited sequence MRI alone. The least accuracy was for US (78.12%) with a statistically significant difference. Due to the significant improvement in the treatment of early stage of HCC compared to the previous decade, we sug...Continue Reading

References

Jul 5, 2001·Seminars in Liver Disease·E K Paulson
Apr 18, 2002·European Radiology·Stavros C Efremidis, Prodromos Hytiroglou
Mar 6, 2007·Journal of Magnetic Resonance Imaging : JMRI·Russell N Low, Jonathan Gurney
Jan 31, 2012·Current Problems in Diagnostic Radiology·Abid IrshadSusan J Ackerman

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imaging technique
biopsies

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