PMID: 6974245Jan 1, 1981Paper

Comparison of the action of La3+ and Ca2+ on contraction threshold and other membrane parameters of frog skeletal muscle

The Journal of Membrane Biology
M Dörrscheidt-Käfer

Abstract

The influence of La3+ on contraction threshold, on membrane input resistance, and on action potential parameters was investigated in fibers of the sartorius muscle of the frog, and it was compared to that of Ca2+. The dependence of the contraction threshold on [La3+]0 in the presence of 0.5mM Ca3+ gave a sigmoid relationship between 0.1 and 5 mM La3+ with a shift of 23 to 34 mV to less negative potentials following a 10-fold increase of [La3+]0. The membrane input resistance was increased to various degrees in La-containing solutions, the increase being irreversible. The threshold of action potential generation was shifted to less negative potentials by 28 mV, and the duration at half-maximal amplitude was tripled by 0.5 mM La3+. In comparison a 10-fold increase of [Ca2+]0 in the range of 0.5 to 50 mM shifted the contraction threshold by 15 mV to less negative potentials. 17 mM Ca3+, a concentration having the same effect on contraction threshold as 0.5 mM La3+, increased membrane input resistance reversibly, shifted the action potential threshold by 16 mV to less negative potentials, and had only minor effects on action potential duration. Conduction was never blocked by Ca3+ as it was with 1 mM La3+. In the theoretical treatm...Continue Reading

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Citations

Feb 1, 1987·Pflügers Archiv : European journal of physiology·C Léoty, J Noireaud
Jan 1, 1983·The Journal of Membrane Biology·M Dörrscheidt-Käfer
Oct 17, 2007·European Biophysics Journal : EBJ·Konstantin OstroumovAndrey Skorinkin
Jan 1, 1985·Progress in Biophysics and Molecular Biology·J CailléO Rougier
Apr 1, 1988·The Journal of General Physiology·R D NathanW Giles
Dec 1, 1988·Biological Trace Element Research·T DasG Talukder

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