PMID: 36117May 1, 1979

Comparison of the actions of diazepam and lorazepam

British Journal of Anaesthesia
J W DundeeJ E Hegarty

Abstract

Diazepam and lorazepam differ in potency and in the time-course of their action. As a sedative, diazepam 10 mg is equivalent to lorazepam 2-2.5 mg. Diazepam is better absorbed after oral than after i.m. administrations but this does not apply to lorazepam. The clinical effect and amnesia begin more rapidly with diazepam, but last longer following lorazepam. Lorazepam is more effective than diazepam in blocking the emergence sequelae from ketamine. Lorazepam i.v. is followed by a lesser frequency of venous thrombosis.

References

Jan 1, 1987·European Journal of Clinical Pharmacology·A PatatM Hucher
Dec 24, 2005·Psychopharmacology·Mark ElliottDoerthe Seifert
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·S G McKenzie
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·M L JackR A O'Brien
Feb 14, 2007·Experimental and Clinical Psychopharmacology·M BoucartChristian Libersa
Jul 22, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Vivek AgarwalPratik Pandharipande
Dec 20, 2002·Clinical Pharmacokinetics·James H FischerPatricia A Fischer
Jul 1, 1994·Psychopharmacology·Pierre VidailhetJ L Imbs
Jan 1, 1988·Cancer Investigation·P L TriozziJ Laszlo
Feb 9, 2010·Pharmacology & Therapeutics·A GierschPierre Vidailhet
May 1, 1991·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·P van der Bijl, J A Roelofse
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J F BishopL G Tan
Jun 1, 1990·Journal of Cardiothoracic Anesthesia·R Ruff, J G Reves
Dec 1, 1984·Acta Anaesthesiologica Scandinavica·H HeikkiläV Laaksonen
Dec 1, 1982·Acta Anaesthesiologica Scandinavica·J Kanto, U Klotz
Jun 1, 1982·Acta Anaesthesiologica Scandinavica·K KorttilaG Abbondati
May 1, 1986·The Journal of Pediatrics·D J LaceyH Gilmore
Jul 13, 2001·Vision Research·T BeckersA Giersch
Mar 1, 1986·Drug Intelligence & Clinical Pharmacy·R C Nelson
Jan 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·O O Akinyemi, S N Awasthi
Apr 1, 1990·Journal of Pharmacokinetics and Biopharmaceutics·S K GuptaD G Heatherly
Sep 24, 2014·The Journal of Trauma and Acute Care Surgery·Jeremiah J DubyChristine S Cocanour
May 1, 1986·Anaesthesia and Intensive Care·A A ArtruB Wright

Related Concepts

Thrombophilia
Anti-Anxiety Effect
Venous Thrombosis
Lorazepam
Amnestic State
Sedatives
Diazepam
Diazepam 10 MG
Hypnotics and Sedatives
Preanesthetic Medication

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