PMID: 6984026Jan 1, 1982Paper

Comparison of the adjuvant effect on antibody response of three types of carrageenan and the cellular events in the induction of the effect

International Journal of Immunopharmacology
S HanazawaK Yamaura

Abstract

The present study was performed in order to demonstrate the adjuvant activity of antibody response of three types of carrageenan (CAR) and the cellular events involved in the adjuvant activity with CAR. CAR-induced enhancing and suppressive effect on primary antibody responses depend greatly on the dose and timing of the injection of the CAR employed. However, neither of these effects were observed in the secondary antibody responses. The maximum adjuvant effect was found when antigen and iota- and lambda-CAR (1 mg) were administered simultaneously to mice, although kappa-CAR did not cause an adjuvant effect. The effect varied with mouse strains tested and the antigen concentration used. It was demonstrated, using athymic nude mice, that the adjuvant effect is independent of T cells. Furthermore, iota- and lambda-CAR polyclonally activated B cells without the help of accessory cells such as macrophages and T cells. This study indicated that the adjuvant effect of CAR is probably independent of macrophages and T cells.

References

Apr 1, 1978·Cellular Immunology·P C QuanG Lespinats
Jan 1, 1979·International Journal of Immunopharmacology·A W ThomsonR G Pugh-Humphreys
Dec 13, 1972·Nature: New Biology·B M Sultzer, B S Nilsson
Aug 1, 1972·European Journal of Immunology·O SjöbergG Möller
Aug 1, 1974·Journal of Immunological Methods·I A Ly, R I Mishell

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Citations

Apr 24, 2021·The Journal of Pain : Official Journal of the American Pain Society·Matthew R SapioAndrew J Mannes

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