PMID: 9551875Apr 29, 1998Paper

Comparison of the angiotensin II receptor antagonist irbesartan with atenolol for treatment of hypertension

Blood Pressure
K O StumpeM Osbakken

Abstract

In this multicenter, double-blind study, the antihypertensive efficacy and safety of irbesartan were compared with those of atenolol in patients with mild-to-moderate hypertension. Following a 4- to 5-week placebo lead-in period, 231 patients with seated diastolic blood pressure (SeDBP) 95-110 mmHg were randomized to irbesartan 75 mg or atenolol 50 mg once daily for 24 weeks. Doses were doubled at Week 6 for SeDBP > or = 90 mmHg. At Week 12, or anytime thereafter, doses were doubled for SeDBP > or = 90 mmHg if not done at Week 6, and hydrochlorothiazide and then nifedipine were added. Efficacy was determined by change from baseline in blood pressure and by therapeutic response rates. Safety was assessed by monitoring adverse events (AEs). Both treatments significantly lowered blood pressure from baseline. There were no significant differences between treatment groups with respect to blood pressure changes or therapeutic response. Atenolol significantly reduced seated heart rate compared with irbesartan at Week 12. The incidences of serious AEs and discontinuations due to AEs were approximately twice as high in the atenolol group compared with the irbesartan group. Thus, in comparison to atenolol, irbesartan < or = 150 mg provid...Continue Reading

References

Jan 1, 1995·Hypertension·A H van den MeirackerA J Man In 't Veld
Jul 1, 1994·American Journal of Hypertension·A Zanchetti
Nov 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K E Bernstein, B C Berk

❮ Previous
Next ❯

Citations

Jul 24, 2001·Blood Pressure. Supplement·G Mancia
Nov 5, 2003·Blood Pressure·Lindon M H WingDanielle Molloy
Mar 20, 2004·Expert Review of Cardiovascular Therapy·Bernard Waeber, Michel Burnier
Feb 24, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Jean-Philippe BaguetPascal Auquier
Jul 16, 2009·Expert Opinion on Pharmacotherapy·Peter BramlageCaroline Hacker
Jul 27, 1999·Journal of Hypertension·W H Birkenhäger, P W de Leeuw
Aug 9, 2003·Expert Opinion on Drug Safety·Neil Shusterman
Dec 24, 2005·Cardiology in Review·Mark J Eisenberg, Laura C Gioia
Jul 17, 2008·Drugs·Katherine F Croom, Greg L Plosker
Feb 15, 2001·Circulation·M Burnier
Jun 14, 2001·Journal of Hypertension·K MalmqvistJ Ostergern
Jul 5, 2005·Expert Opinion on Investigational Drugs·C I Johnston
Mar 15, 2001·Blood Pressure Monitoring·J M Neutel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.