PMID: 6168848Sep 1, 1981Paper

Comparison of the antiarrhythmic efficacy of disopyramide and mexiletine against stimulus-induced ventricular tachycardia

Journal of Cardiovascular Pharmacology
G BreithardtR R Abendroth

Abstract

Programmed ventricular stimulation was used to assess the effect of oral disopyramide (600 mg/day), mexiletine (600--1000 mg/day), and a combination of both drugs in a randomized cross-over study on 12 patients with documented ventricular tachycardia and/or fibrillation. In two cases, all three types of treatment were ineffective in that ventricular tachycardia could still be initiated under the same conditions. In four cases, disopyramide and mexiletine alone were ineffective or the change in inducibility was only slight. However, when both drugs were administered in combination, ventricular tachycardia was more difficult to induce or was no longer inducible. In two other cases, disopyramide was the more effective drug. In the remaining four patients, all three types of treatment were similarly effective. In patients whose ventricular tachycardia remained inducible its rate decreased from 188 +/- 45 bpm (control) to 170 +/- 40 bpm on disopyramide, 172 +/- 31 bpm on mexiletine, and 146 +/- 39 bpm on disopyramide plus mexiletine. Long-term therapy was based on the results of acute testing. Seven patients received both disopyramide and mexiletine and tolerated this therapy well during a follow-up of 42 +/- 23 weeks. Two sudden de...Continue Reading

Citations

Mar 1, 1994·Clinical Cardiology·J A ReiffelR DiBianco
Nov 3, 1988·The American Journal of Cardiology·M V PattB Lown
Jul 1, 1984·Journal of Clinical Pharmacology·R L WoosleyD M Roden
Jan 1, 1984·Annals of the New York Academy of Sciences·G BreithardtL Seipel
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Paulus KirchhofWilhelm Haverkamp
Jan 1, 1987·The New England Journal of Medicine·R W Campbell
Jan 1, 1984·Annals of the New York Academy of Sciences·J W Mason, L M Hondeghem

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