PMID: 2507307Sep 1, 1989Paper

Comparison of the anticonvulsant activities of ethosuximide, valproate, and a new anticonvulsant, thiobutyrolactone

Epilepsia
J A FerrendelliD F Covey

Abstract

Anticonvulsant properties of alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone (alpha-EMTBL) were compared with those of the antiepileptic drugs ethosuximide (ESM) and valproate (VPA) by testing their ability to block seizures in mice caused by maximal electroshock (MES), pentylenetetrazol (PTZ), picrotoxin (PICRO), bicuculline (BIC), methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), N-methyl-D,L-aspartate (NMDA), aminophylline (AMPH), strychnine (STR), beta-ethyl-beta-methyl-gamma-thiobutyrolactone (beta-EMTBL), and t-butylbicyclophosphorothionate (TBPS). ESM was able to prevent PTZ-, PICRO-, DMCM-, and beta-EMTBL-induced seizures. In contrast, VPA and alpha-EMTBL blocked all of these plus MESTBPS-, and BIC-induced convulsions. Only VPA prevented AMPH-induced seizures. None of the anticonvulsants blocked STR or NMDA seizures. Rotorod testing for acute neurotoxicity demonstrated that ESM was the least toxic and alpha-EMTBL and VPA were equivalent. Animals treated daily with high doses of alpha-EMTBL for a 2-week period appeared healthier and had a higher survival rate than animals treated with VPA in the same manner. After a single intraperitoneal (i.p.) injection, the duration of anticonvulsant action of alpha-E...Continue Reading

References

Dec 1, 1987·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M B Robinson, J T Coyle
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Citations

Jan 8, 1998·Journal of Ethnopharmacology·G P Coelho de SouzaM Nascimento da Silva
Jun 1, 1993·The Japanese Journal of Psychiatry and Neurology·R J Porter
Jan 9, 2007·Life Sciences·Carla Cristina Soares VianaPatrícia Pereira
Jul 24, 2020·Behavioural Pharmacology·Pricila PflügerPatrícia Pereira

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