Comparison of the antidiabetic activity of Berberis lyceum root extract and berberine in alloxan-induced diabetic rats

Phytotherapy Research : PTR
M GulfrazE M Williamson

Abstract

Berberine has been shown to have hypoglycaemic activity in several in vitro and in vivo models, although the mechanism of action is not fully known. Berberis lyceum Royle root produces high concentrations of berberine, and in traditional medicine, the whole extract of this plant is used widely to treat diabetes. The antidiabetic activity of the ethanol root extract of Berberis lyceum was compared with pure berberine in normal and alloxan-diabetic rats using similar doses of each. The concentration of berberine in the extract was determined to be 80% dry weight with only trace amounts of other alkaloids present. The purpose of the study was to investigate the effects of berberine and a whole extract of Berberis lyceum on blood glucose and other parameters associated with diabetes, to compare the effects of the crude extract with those of pure berberine and thus validate its use as a therapeutic agent, and finally to identify any contribution of the other components of the extract to these effects. Oral administration of 50 mg/kg of Berberis extract and berberine to normal and experimental diabetic rats produced a significant (p < 0.05) reduction in blood glucose levels from days 3-7 days of treatment. Significant effects were al...Continue Reading

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Citations

Dec 24, 2013·Journal of Ethnopharmacology·Chang-Hua ZhangGuo-Liang Xu
Sep 10, 2015·Molecular Medicine Reports·Han-Ming CuiXiao-Lin Tong
Jul 19, 2012·Fitoterapia·Dipti PotdarSivakami Dhulap
Dec 3, 2014·Journal of Ethnopharmacology·Han-Ming CuiXiao-Lin Tong
Jul 27, 2010·Phytotherapy Research : PTR·Geetha Vani RayasamAbhijit Ray
Dec 10, 2009·Phytotherapy Research : PTR·S K Kulkarni, Ashish Dhir
Apr 5, 2011·European Journal of Pharmacology·Shi-Fen DongJian-Ning Sun
Jul 26, 2015·Journal of Ethnopharmacology·Muhammad Pukhtoon Zada KhanHang Sun
Jul 20, 2016·Journal of Neurogastroenterology and Motility·Mohammad H FarzaeiRoja Rahimi
Mar 16, 2017·Drug Metabolism Reviews·Kun WangFeng Qiu
Jun 24, 2017·Phytotherapy Research : PTR·Hina GulMuhammad Gulfraz
Mar 19, 2019·Clinical and Experimental Pharmacology & Physiology·Dan JiaWeimin Li
Mar 7, 2020·Frontiers in Pharmacology·Tarun BelwalJavier Echeverría
Jul 4, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Muhammad Asad AnwarMuhammad Arshad
Jul 21, 2020·Dose-response : a Publication of International Hormesis Society·Muhammad YounusZulfiqar Ahmad
Jan 12, 2021·Saudi Journal of Biological Sciences·Hina GulGhazala Kaukab Raja

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