PMID: 6165898Apr 1, 1981Paper

Comparison of the antimuscarinic activity of mianserin and amitriptyline in the cat superior cervical ganglion

Naunyn-Schmiedeberg's Archives of Pharmacology
Y H Kwok, F Mitchelson

Abstract

The antimuscarinic activity of mianserin and amitriptyline was investigated in the cat superior cervical ganglion using McN-A-343 as a muscarinic agonist. Mianserin was found to have a similar order of potency to amitriptyline in this preparation, in contrast to the marked difference in their antimuscarinic activities on non-neuronal muscarinic receptors. These findings suggest that the action of mianserin on neuronal muscarinic receptors is more important than that predicted from studies on non-neuronal receptors and may be related to its anti-depressant activity.

References

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