Comparison of the antinociception produced by two oral formulations of ibuprofen: ibuprofen effervescent vs ibuprofen tablets

European Journal of Clinical Pharmacology
T HummelG Kobal

Abstract

The aim of this study was to compare the dose-related effects of both ibuprofen tablets and ibuprofen effervescent [placebo, 400 and 800 mg ibuprofen (Aktren)] on phasic pain. Twenty volunteers participated in this randomized, double-dummy, fivefold crossover study. Measurements were obtained before and 15, 60 and 240 min after drug administration. Pain was produced by CO2 pulses applied to the left nostril. Subjects rated the intensity of the painful stimuli by means of a visual analogue scale. In addition, chemosomatosensory event-related potentials were recorded. In line with previous work, ibuprofen produced a dose-related decrease in pain-related potential amplitudes P1N1, indicating its antinociceptive effects. Higher plasma concentrations of ibuprofen were reached 15-40 min after administration of the effervescent while ibuprofen tablets had a tmax 60-90 min after administration. In addition, 60 min after intake of the effervescent a prolongation of the latencies of the potentials was observed, possibly reflecting superior antinociceptive properties when compared to ibuprofen tablets. In addition, the effervescent appeared to have more consistent effects on intensity estimates compared to ibuprofen tablets.

Citations

Feb 6, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Thomas HummelJörn Lötsch
Apr 1, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·T Hummel
Jun 25, 2005·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·H DoerflerG Kobal
Feb 24, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Elena L R FlohrThomas Hummel
Apr 20, 2007·Journal of Clinical Pharmacology·Bertold RennerKay Brune
Apr 19, 2013·British Journal of Clinical Pharmacology·Lasse Paludan MalverAsbjørn Mohr Drewes
Mar 8, 2005·Brain Research·Antje Welge-LüssenThomas Hummel
Jan 15, 1999·British Journal of Cancer·J A HartleyJ Baumgart
Feb 4, 1999·Annals of the New York Academy of Sciences·T HummelG Kobal

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