Comparison of the antioxidant and vascular effects of gliclazide and glibenclamide in Type 2 diabetic patients: a randomized crossover study

Journal of Diabetes and Its Complications
Michio ShimabukuroNobuyuki Takasu

Abstract

The aim of the present study is to compare the short-term effects of gliclazide and glibenclamide on the oxidative state and vascular endothelium function of Type 2 diabetic patients in an observer-blinded, randomized crossover study. Thirteen Type 2 diabetic patients were enrolled: one group of seven patients took daily 160 mg of gliclazide for the first 4 weeks and then daily 5 mg of glibenclamide for the next 4 weeks; another group of six patients took daily 5 mg of glibenclamide for the first 4 weeks and 160 mg of gliclazide for the next 4 weeks. Forearm blood flow (FBF) measurement for endothelial function and biochemical analyses were conducted before and after each crossover treatment. Four weeks of treatment with either sulfonylurea showed the similar antihyperglycemic effects and enhancement of the peak FBF and total reactive hyperemic flow (flow debt repayment: FDR) during reactive hyperemia. Treatment with gliclazide resulted in the significant reduction to about 60% of baseline in urinary 8-iso-prostaglandin F2alpha (8iPGF2alpha) excretion while no such change was detected in the glibenclamide period. The increases in peak FBF and FDR were in parallel with its anti-hyperglycemic effect, but not with antioxidant stat...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J D MorrowL J Roberts
Sep 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·J SkrhaJ Hilgertová
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·D FavaG De Mattia
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Michio ShimabukuroYuji Matsuzawa
May 25, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·C AntoniadesC Stefanadis
Aug 20, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·M ShimabukuroS Ueda

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