PMID: 7540302Jan 1, 1995Paper

Comparison of the antiviral activities of 3'-azido-3'-deoxythymidine (AZT) and gossylic iminolactone (GIL) against clinical isolates of HIV-1

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
R E RoyerD L Vander Jagt

Abstract

3'-Azido-3'-deoxythymidine (AZT) and gossylic iminolactone (GIL) were compared for antiviral activities in vitro against fresh clinical isolates of HIV-1 obtained from 19 subjects on AZT therapy. IC50 values for AZT ranged from 0.015 to 6.7 microM (447-fold range) while IC50 values for GIL ranged from 0.40 to 6.6 microM (16-fold range). There was no correlation between IC50 values for AZT and GIL, suggesting that the anti-HIV activity of GIL does not involve inhibition of reverse transcriptase.

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Citations

Jan 25, 2003·Journal of Molecular Graphics & Modelling·Paul A KellerRenate Griffith
Nov 14, 1997·AIDS Research and Human Retroviruses·U JunkerE Böhnlein
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Mar 22, 2013·ACS Combinatorial Science·Saurabh MehtaRichard C Larock
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Jun 6, 1996·Death Studies·A Tomer, G Eliason
Aug 19, 2008·Death Studies·Trinda L Power, Steven M Smith
Jan 15, 2014·Omega·Francesco Belviso, Michael D Gaubatz
Jun 4, 2008·Journal of Agricultural and Food Chemistry·Xi WangJ David Gangemi

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