Comparison of the bactericidal activities of ofloxacin and ciprofloxacin alone and in combination with ceftazidime and piperacillin against clinical strains of Pseudomonas aeruginosa.

Antimicrobial Agents and Chemotherapy
M E KlepserCharles H Nightingale

Abstract

On the basis of MIC data, ciprofloxacin exhibits superior activity against Pseudomonas aeruginosa than the other currently available fluoroquinolones do. Despite the antipseudomonal advantage noted for ciprofloxacin monotherapy, it is unknown whether this advantage is maintained when the fluoroquinolones are used in combination with antipseudomonal beta-lactams such as ceftazidime and piperacillin. Twelve healthy volunteers were enrolled in this open-label, randomized, steady-state, six-way cross-over, comparative trial. All subjects received the following regimens: (i) 400 mg of ofloxacin given intravenously (i.v.) every 12 h (q12h), (ii) 400 mg of ciprofloxacin given i.v. q12h, (iii) 400 mg of ofloxacin given i.v. q12h plus 1 g of ceftazidime given i.v. every 8 h (q8h), (iv) 400 mg of ciprofloxacin given i.v. q12h plus 1 g of ceftazidime given i.v. q8h, (v) 400 mg of ofloxacin given i.v. q12h plus 4 g of piperacillin given i.v. q8h, and (vi) 400 mg of ciprofloxacin given i.v. q12h plus 4 g of piperacillin given i.v. q8h. Serum bactericidal titers with subsequent calculation of the area under the bactericidal curve were determined against three clinical isolates of P. aeruginosa. As monotherapy, ciprofloxacin demonstrated supe...Continue Reading

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Citations

May 9, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L NieC H Nightingale
Oct 12, 2002·Diagnostic Microbiology and Infectious Disease·David S Burgess, Surakit Nathisuwan
Jun 19, 2003·Diagnostic Microbiology and Infectious Disease·David S BurgessThomas C Hardin
Apr 30, 1998·Critical Care Clinics·P G AmbroseC H Nightingale
May 1, 1997·International Journal of Antimicrobial Agents·A M ShiblM A Ramadan
Apr 18, 2007·Surgical Infections·Kathryn J EagyeDavid P Nicolau
Jul 13, 2002·American Journal of Therapeutics·Charles O EsimoneMicheal U Adikwu
Apr 24, 2004·Antimicrobial Agents and Chemotherapy·Christine StrijackSheryl A Zelenitsky
Jun 25, 2004·Antimicrobial Agents and Chemotherapy·Joseph L KutiDavid P Nicolau
Mar 21, 2007·Pharmaceutical Research·Trudy Rodgers, Malcolm Rowland
Apr 16, 2014·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Gabriel Trova CubaCarlos Roberto Veiga Kiffer
Apr 29, 1998·Antimicrobial Agents and Chemotherapy·D P NicolauC H Nightingale
Jan 13, 2001·The Medical Clinics of North America·R C Owens, P G Ambrose

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