Comparison of the behavioural pharmacology of the Lister-Hooded with 2 commonly utilised albino rat strains

Progress in Neuro-psychopharmacology & Biological Psychiatry
Claire McDermott, John P Kelly

Abstract

The use of animal models (particularly rats) in research for developing drugs for central nervous system diseases is well validated. However a range of strains are often utilised in these models. The Lister-Hooded (LH) strain is beginning to be increasingly used in preclinical investigations. Thus, the objective of the present study was to investigate the comparative behavioural pharmacology of this strain, with the two most widely used rat strains, namely the Sprague-Dawley (SD), and Wistar (W) strains. The tests used were the forced swim test (FST) for antidepressants, the amphetamine-locomotor activity test for antipsychotics, the elevated plus maze (EPM) for anxiolytics, as well as tests of general locomotor activity using home cage monitoring (HCM) and the open field test. Continuous HCM revealed a significantly higher daily activity and lower nocturnal activity for LH compared to the other strains; there were no strain-related differences in the open field test. In the FST, there were no strain differences in immobility time and a similar magnitude of desipramine-induced reduction in immobility across strains. In the locomotor activity test, control LH rats showed significantly higher activity whilst significant amphetami...Continue Reading

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Citations

Mar 5, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Tina KrollAndreas Bauer
May 15, 2013·Pharmacology, Biochemistry, and Behavior·Melissa MoralesLinda P Spear
Mar 7, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Joy SimpsonJohn P Kelly
Feb 23, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Joy SimpsonJohn P Kelly
Jan 11, 2012·Neuroscience and Biobehavioral Reviews·Colleen M NovakJames A Levine
Apr 2, 2011·Developmental Psychobiology·De-Laine M Cyrenne, Gillian R Brown
Apr 21, 2011·Behavioural Brain Research·Joy Simpson, John P Kelly
Apr 3, 2019·Frontiers in Pharmacology·Paulina ValuskovaJaromir Myslivecek
Nov 21, 2020·Psychopharmacology·Jaime J CastrellonGregory R Samanez-Larkin

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