Comparison of the biological activity of the most common sublingual allergen solutions made by two European manufacturers

International Archives of Allergy and Immunology
Ralph MösgesWalter Lehmacher

Abstract

The clinical efficacy of sublingual immunotherapy has been documented in numerous studies and meta-analyses and is argued to be a favored alternative to the subcutaneous route if allergic symptoms are treated with a high-dose therapy. What is still lacking is a 'conversion rate' between the biological activities of different allergen solutions to determine the one with the higher concentration. A randomized, double-blind, parallel-group study was done with three groups sensitized to the allergens birch, grass or house dust mite via skin prick test. Staloral in the concentrations 10, 100 and 300 IR and SLITone in the concentration of 1,000 STU per milliliter were used for a computer-based comparison of the geometric mean wheal sizes of the different solutions. For each patient, individual regression curves led to the calculation of a mean corresponding IR value for the SLITone solution. A total of 47 patients took part in this clinical trial, most of whom were sensitized to more than one allergen. Values for birch (30 patients) showed that 1,000 STU corresponded to 77 IR, for grass (29 patients) 1,000 STU matched 78 IR and for house dust mite (30 patients) 1,000 STU matched 27 IR based on dose-response relationships. The Wilcoxo...Continue Reading

References

Jan 1, 1993·Allergy
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization
May 6, 2004·Current Opinion in Allergy and Clinical Immunology·Ralph Mösges
Jul 30, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Giovanni PassalacquaGiorgio Walter Canonica
Oct 14, 2004·The Journal of Allergy and Clinical Immunology·Helen SmithAnthony Frew
Oct 14, 2004·The Journal of Allergy and Clinical Immunology·Elio NovembreAlberto Vierucci
Jun 11, 2005·International Archives of Allergy and Immunology·Norbert Reider

❮ Previous
Next ❯

Citations

Oct 25, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Désirée Larenas-LinnemannDerek Constable
May 3, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Désirée Larenas-LinnemannRalph Mösges
May 22, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Désirée Larenas-LinnemannRalph Mösges
Mar 27, 2010·Allergologia et immunopathologia·D Larenas-LinnemannN Rodriguez-Pérez
Mar 3, 2015·Allergy, Asthma & Immunology Research·Kyung Hee ParkJung-Won Park
Jan 7, 2020·Biological & Pharmaceutical Bulletin·Katsuyo Ohashi-DoiKazuhiro Okamiya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.