Comparison of the biological and biochemical activities of several members of the alphaherpesvirus ICP0 family of proteins.

Journal of Virology
Roger D EverettA Orr

Abstract

Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is an E3 ubiquitin ligase of the RING finger class that is required for efficient lytic infection and reactivation from latency. Other alphaherpesviruses also express ICP0-related RING finger proteins, but these have limited homology outside the core RING domain. Existing evidence indicates that ICP0 family members have similar properties, but there has been no systematic comparison of the biochemical activities and biological functions of these proteins. Here, we describe an inducible cell line system that allows expression of the ICP0-related proteins of bovine herpes virus type 1 (BHV-1), equine herpesvirus type 1 (EHV-1), pseudorabies virus (PRV), and varicella-zoster virus (VZV) and their subsequent functional analysis. We report that the RING domains of all the proteins have E3 ubiquitin ligase activity in vitro. The BHV-1, EHV-1, and PRV proteins complement ICP0-null mutant HSV-1 plaque formation and induce derepression of quiescent HSV-1 genomes to levels similar to those achieved by ICP0 itself. VICP0, the ICP0 expressed by VZV, was found to be extremely unstable, which limited its analysis in this system. We compared the abilities of the ICP0-related ...Continue Reading

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Citations

Oct 21, 2011·Molecular Biotechnology·Andreia F CarvalhoJorge E Azevedo
Jul 28, 2010·Journal of Virology·Matthew S WaltersSaul Silverstein
Dec 16, 2011·Journal of Virology·Melanie SchmidThomas Dobner
Jun 15, 2010·PloS One·Mingyu LiuWilliam P Halford
Jun 23, 2011·Future Virology·Emily EshlemanRandall J Cohrs
Jul 19, 2011·Future Virology·Miles C SmithDavid J Davido
Apr 1, 2014·Journal of Invertebrate Pathology·Amélie SegarraTristan Renault
Mar 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yoshitaka MiyagawaJoseph C Glorioso
Mar 22, 2015·The Journal of General Virology·Peter G E KennedyRandall J Cohrs
Dec 15, 2012·The Journal of General Virology·Chris Boutell, Roger D Everett
Apr 30, 2013·Nature Reviews. Microbiology·Roger D EverettBenjamin G Hale
May 24, 2019·Biological Chemistry·Mingsheng CaiMeili Li
May 20, 2014·Expert Review of Vaccines·William P Halford
Dec 31, 2020·Viruses·Christos DogrammatzisMaria Kalamvoki
Feb 19, 2021·Frontiers in Cellular and Infection Microbiology·Mila Collados Rodríguez

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