PMID: 7016264May 1, 1981Paper

Comparison of the clinical effectiveness of lidocaine hydrocarbonate and lidocaine hydrochloride with and without epinephrine in epidural anaesthesia

Canadian Anaesthetists' Society Journal
R MartinL Tétreault

Abstract

Epidural analgesia was administered to one hundred patients undergoing various types of surgical procedures. They were divided at random into four equal groups who received lidocaine hydrocarbonate or lidocaine hydrochloride, both with or without epinephrine. A double blind method was used. The study was designed first to test the validity of claims that lidocaine hydrocarbonate produces a shorter period of onset for effective analgesia, a more profound sensory and motor block, and a higher spread of analgesia than the hydrochloride salt and secondly, to identify the respective roles of carbon dioxide and epinephrine in obtaining this alleged superior effectiveness. The results of the study showed that carbon dioxide improved the quality of sensory block, but we could not find any significant difference between lidocaine hydrocarbonate and lidocaine hydrochloride salt, with and without epinephrine, with regard to rapidity of onset, upward spread of analgesia and quality of motor block. As was already known, duration of analgesia was prolonged by the addition of epinephrine but not by the addition of carbon dioxide. They study also showed that the compliance of the epidural space was decreased in the lidocaine hydrocarbonate gro...Continue Reading

References

Jan 1, 1965·Acta Anaesthesiologica Scandinavica. Supplementum·P R Bromage
Nov 1, 1970·Canadian Anaesthetists' Society Journal·P R Bromage
Mar 1, 1967·British Journal of Anaesthesia·P R BromageA P Truant

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Citations

Apr 1, 1990·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D J LiepertP L Ross
Mar 1, 1983·Canadian Anaesthetists' Society Journal·D A MageeA J Holland
Nov 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·R MartinJ P Tétrault
Dec 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D H Morison
Oct 1, 1991·Acta Anaesthesiologica Scandinavica·M SolakE Duman
Oct 16, 2004·International Journal of Dermatology·Hiroko AraiEckart Haneke
Apr 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D ChassardP Boulétreau
Apr 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P GosteliA Forster

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