Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: A randomised placebo-controlled clinical trial

Andrologia
M Abu El-Hamd, A Abdelhamed

Abstract

The aim of the study was to compare the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation (PE). In a single-blind placebo-controlled clinical study, 150 PE patients without erectile dysfunction (ED) were included during the period of March 2015 to May 2016. Patients were randomly divided into five groups (30 patients each). On demand placebo, paroxetine (30 mg), dapoxetine (30 mg), sildenafil citrate (50 mg) and combined dapoxetine (30 mg) with sildenafil citrate (50 mg) were given for patients for 6 weeks in each group respectively. All patients were instructed to record intravaginal ejaculatory latency time (IELT) and evaluated with Premature Ejaculation Diagnostic Tool (PEDT) and the patient satisfaction score before and after treatment. The mean of IELT, satisfaction score and PEDT in all groups was significantly improved after treatment (p value = .001). Combined dapoxetine with sildenafil group had the best values of IELT, satisfaction scores and PEDT in comparison with other treatment groups (p value <.001). The combined dapoxetine with sildenafil therapy could significantly improve PE patient...Continue Reading

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Citations

Sep 19, 2018·International Urology and Nephrology·Zhongyu JianKunjie Wang
Jun 21, 2018·International Journal of Impotence Research·Kannan SridharanKhalid Aj Al-Khaja
Mar 7, 2019·International Journal of Impotence Research·Pramod KrishnappaJuan Ignacio Martinez-Salamanca
Nov 17, 2019·Medical Sciences : Open Access Journal·Nicholas Gillman, Michael Gillman
Nov 24, 2020·Fundamental & Clinical Pharmacology·Moein AlaAhmad Reza Dehpour
Jan 15, 2021·Nature Reviews. Urology·Elena ColonnelloEmmanuele A Jannini
Mar 22, 2021·The Cochrane Database of Systematic Reviews·Niranjan J SathianathenPhilipp Dahm

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