Comparison of the contractile properties, oxidative capacities and fibre type profiles of the voluntary sphincters of continence in the rat.

Journal of Anatomy
M BuffiniJ F X Jones

Abstract

The external urethral sphincter (EUS) and external anal sphincter (EAS) are the principal voluntary striated muscles that sustain continence of urine and faeces. In light of their common embryological origin, shared tonic sphincteric action and synchronized electrical activity in vivo, it was expected that they would exhibit similar physiological and structural properties. However, the findings of this study using paired observations of both sphincters isolated from the rat show clearly that this is not the case. The anal sphincter is much more fatigable than the urethral sphincter. On completion of a fatigue protocol, the amplitude of the last twitch of the EAS had declined to 42 +/- 3% of the first twitch, whereas the last twitch of the EUS was almost identical to that of the first (95 +/- 3%). Immunocytochemical detection of myosin heavy-chain isoforms showed that this difference was not due to the presence of more slow-twitch oxidative type 1 fibres in the EUS compared with the EAS (areal densities 4 +/- 1% and 5 +/- 1%, respectively; P = 0.35). In addition, the fatigue difference was not explained by a greater contribution to force production by fast oxidative type 2A fibres in the urethral sphincter. In fact, the anal sph...Continue Reading

References

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Jan 1, 1996·International Urogynecology Journal and Pelvic Floor Dysfunction·B RussellA Svanborg
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Mar 28, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C F HealyJ F X Jones
Aug 14, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M BanahanJ F X Jones

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Citations

Nov 16, 2013·Acta histochemica·Kenia López-GarcíaFrancisco Castelán
May 28, 2013·Experimental Physiology·R A O'ConnellK D O'Halloran
Jul 9, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Seh Hong LimChen-Li Cheng
Jan 13, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M BuffiniJ F X Jones
Mar 25, 2014·Autonomic Neuroscience : Basic & Clinical·Z Al-NoahF Aura Kullmann
Sep 28, 2016·Neurourology and Urodynamics·Kenia López-GarcíaIsmael Jiménez-Estrada
Jul 2, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Toshiko Tsumori, Wakako Tsumiyama
Apr 9, 2018·Irish Journal of Medical Science·James F X Jones
May 10, 2017·Diseases of the Colon and Rectum·Judith EversP Ronan O'Connell
Oct 23, 2018·Biology of Sex Differences·Benjamin AbelsonMargot S Damaser

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