Comparison of the Conventional and Electroenhanced Direct-Immersion Solid-Phase Microextraction for Sampling of Nicotine in Biological Fluids of the Human Body

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Sana AbdolhosseiniNahid Heidari

Abstract

A stainless steel fiber was made porous and adhesive by platinization and then coated by nanostructured polypyrrole (PPy), using an appropriate electrophoretic deposition (EPD) method. The morphological surface structure and functional groups of the PPy-coated fiber were studied using SEM (Scanning electron microscope) instrument. The prepared fiber was used for comparison of direct immersion (DI) and electroenhanced direct immersion solid-phase microextraction (EE-DI-SPME) of nicotine in human plasma and urine samples followed by gas chromatography flame ionization detector (GC-FID) determination. The effects of the influential experimental parameters on the efficiency of the DI-SPME and EE-DI-SPME methods, including the pH and ionic strength of the sample solution, applied Direct current (DC) voltage, extraction temperature and time and stirring rate, were optimized. Under the optimal conditions, the calibration curves for the DI-SPME-GC-FID and EE-DI-SPME-GC-FID methods were linear over the ranges of 0.1⁻10.0 μg mL-1 and 0.001⁻10.0 μg mL-1, respectively. The relative standard deviations (RSDs, n = 6) were found to be 6.1% and 4.6% for the DI and EE strategies, respectively. The LODs (limit of detection) of the DI-SPME-GC-FID...Continue Reading

References

Feb 1, 1974·Food and Cosmetics Toxicology·K D Brunnemann, D Hoffmann
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Jul 12, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sana AbdolhosseiniNahid Heidari
Jul 29, 2017·Physical Chemistry Chemical Physics : PCCP·Jingping WangJianbo Zhu

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