Comparison of the decreases in regional cerebral blood flow in the posterior cingulate cortex, precuneus, and parietal lobe between suspected non-Alzheimer's disease pathophysiology and Alzheimer's disease.

Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society
Hiroshi HayashiKoichi Otani

Abstract

Suspected non-Alzheimer's disease pathophysiology (SNAP) shows Alzheimer's disease (AD)-like neurodegeneration; however, amyloid β, which is a biological marker in AD, remains within normal levels. Since the effectiveness of anti-dementia drugs for AD on SNAP is unknown, it is important to distinguish between patients with SNAP and AD. We aimed to compare decreases in regional cerebral blood flow (rCBF) of the posterior cingulate cortex (PCC), precuneus, and parietal lobe critical to AD between SNAP and AD groups using the easy Z-score imaging system in single-photon emission computed tomography (eZIS-SPECT). We retrospectively analysed eZIS-SPECT data of 13 SNAP and 24 AD patients. The three indicators (severity, extent, and ratio) that distinguished AD patients from healthy controls in previous studies were automatically calculated and were compared between the SNAP and AD groups. Receiver operating characteristic curve analysis and the area under the curve (AUC) were used to evaluate the diagnostic performance of the three indicators of eZIS in discriminating between the two groups. The mean values of severity, extent, and ratio were significantly lower in the SNAP group than in the AD group (P = 0.024, P = 0.044, and P = 0....Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jan 15, 2004·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masahito Yamada
Sep 30, 2004·Journal of Neuropathology and Experimental Neurology·Yuko SaitoShigeo Murayama
Jan 12, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Markus Tolnay, Florence Clavaguera
Nov 8, 2006·Acta Neuropathologica·K A Jellinger, J Attems
Apr 12, 2008·Cerebral Cortex·Michael D GreiciusRobert F Dougherty
Jun 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas VillainGaël Chételat
Oct 29, 2014·Acta Neuropathologica·John F CraryPeter T Nelson
Jan 9, 2015·Neurology·Anna CaroliUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 13, 2016·Neurology·Susan M LandauUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 21, 2017·JAMA Neurology·Stefanie SchreiberUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
May 11, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Rola IsmailDavid J Brooks
Jun 9, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Val J LoweMelissa E Murray
Aug 1, 2020·Neurobiology of Aging·Jilu P MoleClaudia Metzler-Baddeley

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