PMID: 7085899May 1, 1982Paper

Comparison of the diagnostic value of serum pancreatic isoamylase and immunoreactive trypsin measurement in patients with cystic fibrosis

Journal of Clinical Pathology
R C BrownM S Losowsky

Abstract

We have measured serum immunoreactive trypsin (IRT) and serum pancreatic isoamylase (PIA) activities using commercially available kits in 37 cystic fibrosis (CF) patients and 46 hospital controls of similar age range. Immunoreactive trypsin was more often abnormal than PIA (26/37 v 18/37 abnormal respectively); IRT will be particularly useful as an additional diagnostic test in older children, in whom interpretation of the sweat test may be difficult, as 14/15 CF patients aged over 10 years had abnormal IRT results. Less than half of our patients who were aged between one and nine years had abnormal IRT activity, limiting the value of the test, though a low activity would still support the diagnosis of CF. Comparison with faecal fat estimations in 31 patients suggests that neither IRT nor PIA can be used as a non-invasive test of pancreatic function in order to identify those few CF patients who do not require pancreatic enzyme supplements.

References

Aug 19, 1978·Lancet·C A SmalleyC M Anderson
Jan 1, 1975·Journal of Surgical Oncology·J M Kissane
Nov 1, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·D KennyK F McGeeney
Apr 22, 1976·The New England Journal of Medicine·B H Bowman, J A Mangos
Mar 1, 1976·Acta paediatrica Scandinavica·G Skude, H Kollberg
Jan 1, 1981·Thorax·P DandonaJ C Batten
Oct 1, 1980·The American Journal of Medicine·P B DavisP A Di Sant'Agnese

Citations

Oct 7, 2004·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M SinaasappelG Döring
Nov 26, 1999·The Australasian Journal of Dermatology·B M WelshG A Varigos
Aug 13, 1983·British Medical Journal·J M Littlewood
Oct 27, 2011·Journal of Experimental & Clinical Cancer Research : CR·Maren FedrowitzWolfgang Löscher
Aug 11, 2000·Paediatric Drugs·J M Littlewood, S P Wolfe
Oct 1, 1984·Clinical Biochemistry·M HjelmP Quartey-Papafio
Nov 17, 2005·Pediatric Pulmonology·James M LittlewoodSteven P Conway
Jan 2, 1985·Klinische Wochenschrift·P MalfertheinerH Ditschuneit

Related Concepts

Pulmonary Cystic Fibrosis
Feces
Exoglycosidases
Isoamylase
Lipids
Pancreas
In Vitro Diagnostic Devices
Trypure

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.