Comparison of the diagnostic value of symmetric dimethylarginine, cystatin C, and creatinine for detection of decreased glomerular filtration rate in dogs

Journal of Veterinary Internal Medicine
L PelanderI Ljungvall

Abstract

Early detection of decreased glomerular filtration rate (GFR) in dogs is challenging. Current methods are insensitive and new biomarkers are required. To compare overall diagnostic performance of serum symmetric dimethylarginine (SDMA) and serum cystatin C to serum creatinine, for detection of decreased GFR in clinically stable dogs, with or without chronic kidney disease (CKD). Ninety-seven client-owned dogs: 67 dogs with a diagnosis or suspicion of CKD and 30 healthy dogs were prospectively included. Prospective diagnostic accuracy study. All dogs underwent physical examination, systemic arterial blood pressure measurement, urinalysis, hematology and blood biochemistry analysis, cardiac and urinary ultrasound examinations, and scintigraphy for estimation of glomerular filtration rate (mGFR). Frozen serum was used for batch analysis of SDMA and cystatin C. The area under the curve of creatinine, SDMA, and cystatin C for detection of an mGFR <30.8 mL/min/L was 0.98 (95% confidence interval [CI], 0.93-1.0), 0.96 (95% CI, 0.91-0.99), and 0.87 (95% CI, 0.79-0.93), respectively. The sensitivity of both creatinine and SDMA at their prespecified cutoffs (115 μmol/L [1.3 mg/dL] and 14 μg/dL) for detection of an abnormal mGFR was 90%. ...Continue Reading

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Citations

Jul 21, 2020·American Journal of Physiology. Renal Physiology·G Ryan CrislipPaul M O'Connor
Nov 14, 2020·The Journal of Small Animal Practice·H J SargentR E Jepson
Jan 16, 2021·Acta Veterinaria Scandinavica·Natalia SiwinskaUrszula Paslawska
Mar 19, 2021·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Barbara SzczepankiewiczRobert Pasławski
Mar 24, 2021·Journal of the American Veterinary Medical Association·Maureen A GriffinMason W Wanamaker
Jan 22, 2022·Veterinary Research Communications·Naoki IwasaNaohito Nishii

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