PMID: 2118317Sep 1, 1990Paper

Comparison of the direct effects of halothane and isoflurane on large and small coronary arteries isolated from dogs

Anesthesiology
Y HatanoF C Anaes

Abstract

Relaxant responses to halothane and isoflurane were compared in helical strips of dog epicardial coronary arteries of different sizes: proximal large coronary arteries with outside diameters (OD) larger than 2.5 mm and distal small arteries with 0.7-0.9 mm OD. Responses to pharmacologic vasodilators, including nitroglycerin (NTG) and adenosine, were also studied for comparison. The relaxation induced by halothane in concentrations of 0.8-2.3% and by NTG (10(-9)-10(-5) M) was greater in proximal large coronary arteries than in distal small ones contracted with 20 mM KCl. In contrast, the relaxation by isoflurane (1.2-3.5%) and by adenosine (10(-8)-10(-4) M) was greater in small coronary arteries than in large ones. These results suggest that isoflurane is, like adenosine, preferentially a small artery dilator.

Citations

Oct 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M YamamotoK Mori
Nov 1, 1995·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T AkataS Takahashi
Apr 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K OgawaY Hatano
Mar 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K NakamuraK Mori
Nov 2, 2005·Journal of Anesthesia·Mitsuhiro TakemuraYoshihisa Koga
Nov 12, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Oliver KimbergerAndrea Kurz
Apr 11, 2000·Acta Anaesthesiologica Scandinavica·E HaddadB Vallet
May 23, 2003·Anesthesia and Analgesia·Tanja A TreschanAndrea Kurz
Aug 15, 2006·Journal of Clinical Anesthesia·Shunji KobayashiShigehito Sato
Dec 9, 2014·Current Opinion in Anaesthesiology·Carolien S E BulteStephan A Loer
Jun 12, 1999·Annales Françaises D'anesthèsie Et De Rèanimation·A BoillotF Barale

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