Comparison of the direct effects of sevoflurane, isoflurane and halothane on isolated canine coronary arteries

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
K NakamuraK Mori

Abstract

We have demonstrated previously, using dog epicardial arteries of different sizes, that isoflurane, like adenosine, is preferentially a small coronary artery dilator, whereas halothane, like nitroglycerin, is a large artery dilator. The present study was designed to compare the direct effects of sevoflurane with those of isoflurane and halothane. Proximal large coronary arteries with an outer diameter (o.d.) of 2.5-3.2 mm and distal small arteries of 0.6-0.9 mm o.d. were isolated from dogs and then cut into vascular rings. They were precontracted with KCl (20 mM), and their relaxant responses to anaesthetics were compared relative to the maximal responses induced by papaverine. Sevoflurane, halothane and isoflurane (1-3 human MAC) induced dose-dependent relaxation of these arteries. The relaxant response to sevoflurane did not differ between large and small arteries. However, the relaxant response of the large arteries to halothane (1.5-2.3%) was greater than that of small arteries (P < 0.01) and the response of small arteries to isoflurane (3.5%) was greater than that of large arteries (P < 0.05). In large arteries, the potency of the relaxant effect at equivalent human MAC could be ranked as halothane > or = sevoflurane > iso...Continue Reading

References

Mar 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M W CrawfordF J Carmichael
Jan 1, 1992·Anesthesia and Analgesia·P F ConzenK Messmer
Mar 1, 1987·Anesthesiology·T Katoh, K Ikeda
Jul 1, 1972·The American Journal of Physiology·R L Schnaar, H V Sparks
May 1, 1968·Circulation Research·W M Fam, M McGregor
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Citations

Apr 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K NakamuraK Mori
Sep 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N R SearleL R Hodgins
Nov 1, 1995·Journal of Clinical Anesthesia·C J Young, J L Apfelbaum
Dec 17, 2014·The Journal of Obstetrics and Gynaecology Research·Ergun GunduzAtes Duman
May 25, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Sota OkamotoTatsuya Ichinohe
Oct 29, 2000·Journal of Cardiothoracic and Vascular Anesthesia·M S MikhailP A Chandraratna
Jun 1, 1996·Anesthesiology·G J Crystal
Dec 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·John S IkonomidisFrancis G Spinale
Nov 1, 1995·Anesthesia and Analgesia·B M GrafD F Stowe
Oct 3, 2006·Current Opinion in Anaesthesiology·N Nader-Djalal, P R Knight
Mar 1, 1998·Journal of Anesthesia·Kazu-Ichi Yoshida, Akiyoshi Ohsawa
Jun 12, 1999·Annales Françaises D'anesthèsie Et De Rèanimation·A BoillotF Barale

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