Comparison of the effect of 6% hydroxyethyl starch and gelatine on cardiac and stroke volume index: a randomized, controlled trial after cardiac surgery

Perfusion
Alexey A SchramkoTomi T Niemi

Abstract

The objective of this study was to find out the effect of various doses of hydroxyethyl starch (HES), gelatine or Ringer's acetate on cardiac and stroke volume index after cardiac surgery. Three consecutive boluses (each 7 mL·kg(-1)) of either 6% HES 130/0.4, 4% gelatine, or Ringer's acetate solutions were administered to 45 patients postoperatively. The rate of infusions was adjusted according to haemodynamic measurements. Thereafter, infusion of the study solution (7 mL·kg(-1)) was continued for the following 12 hours. The total dose of study solution was 28 mL·kg(-1). Mean (SD) cardiac and stroke volume indices were greater in the HES group [2.8 L·min(-1)·m(-2) (0.7), 34.1 (6.7) ml·m( -2)] than in the gelatine group [2.2 L·min(-1)·m( -2) (0.6), 25.8 (7.2) ml·m(-2)] after completion of 7 mL·kg(-1) of study solution. At this stage, the effect of gelatine did not differ from Ringer's acetate. After completion of 14 mL·kg(-1) and 21 mL·kg(-1) of colloids, similar cardiac and stroke volume indices were observed and the haemodynamic response was better in both colloid groups than in the Ringer's acetate group. No differences between groups were detected on the first postoperative morning. In the early postoperative phase after car...Continue Reading

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Citations

Feb 26, 2011·Der Anaesthesist·B NohéK Unertl
Apr 25, 2012·Intensive Care Medicine·D O Thomas-RueddelC S Hartog
Jul 25, 2013·American Journal of Veterinary Research·Duana McBrideLisa Smart
May 15, 2012·The Journal of Thoracic and Cardiovascular Surgery·Roberta J NavickisMahlon M Wilkes
Feb 12, 2014·The Journal of International Medical Research·Holger KrebbelClaudia Spies
Aug 1, 2020·Acta Anaesthesiologica Scandinavica·Timo KoponenPasi Lahtinen

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